S100A14在消化系统肿瘤中的研究进展

Research progress of S100A14 in digestive system tumors

S100A14是多功能S100蛋白家族的成员之一,具有广泛的生物学功能,如细胞增殖、分化与凋亡、侵袭与转移等。它在多种肿瘤中的表达具有细胞和组织特异性,而且表达水平与患者预后相关。S100A14在消化系统肿瘤中,主要通过与靶蛋白结合发挥其作用与功能,但作用机制尚未完全阐明。笔者就S100A14的分子结构与功能,及其在消化系统肿瘤中表达情况及作用机制进行综述。

S100A14 is one of the multifunctional S100 protein family members,which is involved in a wide range of biological functions,such as cell proliferation,differentiation and apoptosis,invasion and metastasis.Its expression presents cell and tissue specificity in a variety of tumors,and its expression level is related to the prognosis of patients.In digestive system tumors,S100A14 exerts its function mainly through binding to the target protein,but the action mechanism has not been fully elucidated.Here,the authors review the molecular structure and function of S100A14,and its expression and action mechanism in the digestive system tumors.