补肾活血方辅助治疗对卵巢储备功能下降患者血清FSH、LH、E_(2)水平影响

Effect of Reinforcing Kidney and Activating Blood Recipe on Serum FSH,LH,E_(2) Levels in Patients with Diminished Ovarian Reserve

目的研究补肾活血方辅助治疗对卵巢储备功能下降患者血清FSH、LH、E_(2)水平影响。方法回顾性分析2017年3月—2020年3月收治的80例卵巢储备功能下降患者,将所有患者分为对照组(38例)和治疗组(42例)。对照组患者口服复方戊酸雌二醇片治疗,治疗组在对照组的基础上服用补肾活血方治疗,7 d为一个疗程,2组均持续治疗4个疗程。比较治疗后2组患者临床疗效、治疗前后AFC、双侧平均卵巢体积及血清FSH、LH、E_(2)水平变化。结果治疗组患者的临床总有效率为95.24%,比对照组的76.32%高;治疗后2组患者AFC较治疗前增多,且治疗组多于对照组,双侧平均卵巢体积较治疗前增大,且治疗组比对照组大;治疗后2组血清E_(2)水平均升高,且治疗组比对照组高,血清FSH、LH水平均下降,且治疗组低于对照组(均P <0.05)。结论补肾活血方可有效缓解卵巢储备功能下降患者的临床症状,改善卵泡生殖及卵巢储备功能,调节雌激素水平,促进卵泡排出。

Objective To study the effect of reinforcing kidney and activating blood recipe on serum FSH,LH and E_(2) levels in patients with diminished ovarian reserve. Methods Retrospective analysis of 80 patients with decreased ovarian reserve function admitted to our hospital from March 2017 to March 2020 were selected and randomly divided into the control group( n = 38) and the treatment group( n = 42). The control group was treated with compound estradiol valerate tablets,while the treatment group was treated with reinforcing kidney and activating blood recipe on the basis of the control group. 7 days was a course of treatment. Both groups continued to treat for 4 courses. The clinical efficacy after treatment,the changes of AFC,bilateral mean ovarian volume and serum FSH,LH,E_(2) levels were observed before and after treatment. Results The clinical effective rate of the treatment group was 95. 24%,which was higher than 76. 32% of the control group. After treatment,AFC of the two groups increased compared with that before treatment,and the treatment group was more than the control group,the bilateral average ovarian volume was larger than that before treatment,and the treatment group was larger than the control group. After treatment,the serum E_(2) level of the two groups increased,and the control group was lower than the treatment group,and the serum FSH and LH levels decreased,and the treatment group was lower than the control group( all P < 0. 05). Conclusion Reinforcing kidney and activating blood recipe can effectively relieve the clinical symptoms of patients with diminished ovarian reserve,improve follicular reproduction and ovarian reserve function,regulate estrogen level and promote follicular discharge.