摘要
新型冠状病毒的变异,尤其是S蛋白的突变,成为现在关注的焦点,其中S蛋白的D614G的突变株迅速成为全球流行株,有研究显示其增强了复制力和感染力。现就D614G突变株引起的生物学改变和潜在分子机制等研究作一概述。
Objective The major mutations detected in the SARS-CoV-2 viral envelope spike(S) protein have become the focus of attention now. Among them, the D614 G variant of S protein has rapidly become dominant during the COVID-19 pandemic worldwide, and some studies have shown its ability to enhance replication and infectivity. This paper summarizes the research progress of biological changes induced by the D614 G variant and its underlying mechanism.
作者
路琼
黄维金
王佑春
LU Qiong;HUANG Wei-jin;WANG You-chun(National Institutes for Food and Drug Control,Key Laboratory of National Health Commission of the People’s Republic of China for Research on Quality and Standardization of Biotech Products,Key Laboratory of Biological Product Quality Research and Evaluation of State Drug Administration,Beijing 102629,China)
出处
《微生物学免疫学进展》
CAS
2021年第2期73-77,共5页
Progress In Microbiology and Immunology
基金
2020年度国家自然科学基金面上项目(3207040633)。
关键词
新型冠状病毒肺炎
严重急性呼吸道综合征冠状病毒2型
变异
Corona virus disease 2019(COVID-19)
Severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2)
Variation
