2019冠状病毒病对肺外系统的影响及可能机制探讨

Extrapulmonary impairments in COVID-19 patients and the potential mechanisms

2019冠状病毒病(coronavirus disease 2019,COVID-19)是由严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)导致的感染性疾病。SARS-CoV-2感染人体后除作用于肺部的SARS-CoV-2功能受体外,还可以作用于心脏、消化道、肝脏、肾脏、中枢系统的SARS-CoV-2功能受体,引起肺外脏器的损伤,诱发多器官功能衰竭,增加COVID-19的病死率。但目前对SARS-CoV-2引起肺外各脏器损伤的具体作用机制还不是很清楚,需要更多临床和实验室数据支持。通过检索COVID-19相关的文献,对SARS-CoV-2导致的肺外系统影响及其可能作用机制作一综述。

Coronavirus disease 19(COVID-19)related studies that were published on journals and medRxiv were reviewed to explore effects of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)on extrapulmonary organs and its potential mechanisms.In addition to respiratory organs,the expression of SARS-CoV-2 functional receptor has also been observed in human hearts,gut,liver,kidneys,and central nervous systems.The action of SARS-CoV-2 on extrapulmonary receptors may contribute to multiple organ dysfunction and the high mortality rate of COVID-19.However,the exact mechanism leading to extrapulmonary impairments in COVID-19 patients remains elusive and further research is needed to provide more evidence.