间充质干细胞促进肿瘤发生发展的机制研究进展

Research advances in mechanisms of mesenchymal stem cells promoting tumor progression

间充质干细胞(mesenchymal stem cells,MSCs)是一类起源于中胚层的成体干细胞,因具有良好的增殖能力、低免疫原性、靶向归巢肿瘤等特性,且易于体外分离培养和基因修饰改造,已成为肿瘤生物学研究的热点。研究表明MSCs具有促进肿瘤生长、增殖、转移和介导化疗耐药等作用,可以考虑作为抗肿瘤治疗的靶点。本文综述了MSCs促进肿瘤发生发展过的相关机制,为寻找潜在的治疗靶点提供参考依据。

Mesenchymal stem cells(MSCs)are a kind of adult stem cells originated from mesoderm,which have become a hot spot in tumor biology research because of their characteristics such as excellent proliferative ability,low immunogenicity,homing to the targeted cancerous tissues,etc.Besides,they are easy to be isolated,cultured in vitro and genetically modified.Studies have shown MSCs can promote tumor growth,proliferation,metastasis and mediate chemoresistance,thus they can be considered as a target for anti-tumor therapy.In this paper,the relevant roles of MSCs in promoting tumorigenesis and progression are reviewed to provide references and evidences for the benefit of looking for potential therapeutic targets.