低氧诱导因子与冠心病:拮抗与保护

Hypoxia-inducible factor and coronary heart disease: antagonism and protection

背景:低氧诱导因子作为低氧反应过程中的核心转录因子,参与许多生理和病理生理过程。近年来研究发现,低氧诱导因子在冠心病的病理生理过程和治疗中发挥至关重要的作用。目的:总结低氧诱导因子在冠心病病理生理过程中的研究进展。方法:应用计算机检索2010年1月至2020年10月PubMed、Web of Science、中国知网和中国生物医学文献数据库,中文关键词为“低氧诱导因子,冠心病,心肌梗死、心绞痛”;英文关键词为“hypoxia inducible factor,coronary heart disease,myocardial infarction,angina pectoris”。中文数据库的检索式为((低氧诱导因子)AND((冠心病)OR(心肌梗死)OR(心绞痛))),英文数据库的检索式为((((coronary heart disease[Title])OR(myocardial infarction[Title]))OR(angina pectoris[Title]))AND((HIF[Title])OR(hypoxia inducible factor[Title])))。中文数据库共获得51篇文献,英文数据库共获得44篇文献。通过限定发文时间,再阅读标题和摘要,最终纳入38篇文献进行综述。结果与结论:低氧诱导因子通过促进血管生成、抑制心肌细胞凋亡、减轻炎症反应、遏制心肌细胞自噬和抗心肌纤维化等多种信号通路发挥对梗死心肌的保护。

BACKGROUND:As a core transcription factor in the hypoxia response process,hypoxia-inducible factors participate in many physiological and pathophysiological processes.In recent years,hypoxia inducible factors play a vital role in the pathophysiological process and treatment of coronary heart disease.OBJECTIVE:To summarize the application of hypoxia-inducible factors in the pathophysiological process of coronary heart disease.METHODS:English literatures published during January 2010 to October 2020 were retrieved from PubMed and Web of Science,and Chinese literatures published during January 2010 to October 2020 were retrieved from CNKI and the Chinese Biomedical Literature Database.Search terms were“hypoxia inducible factor,coronary heart disease,myocardial infarction,angina pectoris”in English and Chinese,respectively.The search strategy for Chinese databases was((hypoxia inducible factor)AND((coronary heart disease)OR(myocardial infarction)OR(angina pectoris))),and the search strategy for English databases was((((coronary heart disease[Title])OR(myocardial infarction[Title]))OR(angina pectoris[Title]))AND((HIF[Title])OR(Hypoxia inducible factor[Title]))).There were 51 articles in Chinese and 44 articles in English.By limiting the time of publication,and then reading the title and abstract,38 articles were finally included for review.RESULTS AND CONCLUSION:Hypoxia-inducible factors prevent against myocardial infarction by promoting angiogenesis,inhibiting apoptosis in cardiomyocytes,eliminating inflammatory responses,preventing cardiomyocyte autophagy and resisting myocardial fibrosis.