影像基因组学在肝细胞癌诊疗中的应用研究进展

Research progress of radiogenomics in diagnosis and treatment of hepatocellular carcinoma

肝细胞癌(HCC)的发病率和病死率较高,早期精准诊疗对病人的预后至关重要。以形态学为主的影像诊断模式已不能满足临床需求。影像组学能深度挖掘影像提供的庞大数据信息,采用定量数据分析综合评价基因遗传、细胞分子、组织形态等各层次HCC的表型,从而对HCC进行精准诊疗和无创监测;基因组学从分子及基因层面揭示HCC的发病机制;影像基因组学主要为HCC形态学特征和影像组学表型特征与基因组学的关联。就HCC的影像基因组学研究进展进行综述。

Objective Hepatocellular carcinoma(HCC)causes high morbidity rate and mortality rate.Accurate diagnosis and treatment are significant to the prognosis of HCC patients.The morphology-based imaging diagnosis model can no longer meet clinical needs.People could use radiomics to mine more data information from images,and use quantitative data analysis methods to evaluate the phenotype of HCC at all levels,such as genetic inheritance,cell molecular,and tissue morphology,so as to perform accurate diagnosis and non-invasive monitoring of HCC.Genomics reveals the pathogenesis of tumors from the molecular and genetic level.Radiogenomics is mainly related to morphological and radiomic features and genomic results.This article reviews the progress of radiogenomics of HCC.