糖尿病肾病血小板活化标志物CD62P、CD63及ET-1的表达研究

Study on expression of platelet activation markers CD62P,CD63 and ET-1 in diabetic nephropathy

目的分析糖尿病肾病血小板活化标志物P-选择素(CD62P)、溶酶体颗粒糖蛋白(CD63)及内皮素(ET)-1的表达情况。方法选取90例糖尿病肾病患者(糖尿病肾病组)、30例无糖尿病肾病的糖尿病患者(无糖尿病肾病的糖尿病组)及30例健康体检者(健康对照组)作为研究对象,检测并比较三组研究对象的CD62P、CD63及ET-1水平。结果糖尿病肾病组CD62P、CD63及ET-1水平分别为(8.21±2.45)%、(15.68±3.36)%、(2.83±1.05)pg/ml,均高于无糖尿病肾病的糖尿病组的(5.56±2.32)%、(7.61±2.17)%、(2.31±0.37)pg/ml,差异有统计学意义(P<0.05)。糖尿病肾病组CD62P、CD63及ET-1水平均高于健康对照组,差异有统计学意义(P<0.05)。无糖尿病肾病的糖尿病组CD62P、CD63及ET-1水平均高于健康对照组,差异有统计学意义(P<0.05)。结论糖尿病肾病患者血小板活化标志物CD62P、CD63及ET-1的表达均较高,临床上可通过抗血小板活化药物进行治疗,可为糖尿病肾病后续治疗提供重要依据,值得进一步研究。

Objective To analyze the expression of platelet activation markers P-selection(CD62P),lysosome intact membrane protein(CD63)and endothelin-1(ET-1)in diabetic nephropathy.Methods There were 90 patients with diabetic nephropathy(diabetic nephropathy group),30 diabetic patients without diabetic nephropathy(non-diabetic nephropathy group)and 30 healthy subjects(healthy control group)as study subjects,and the levels of CD62P,CD63 and ET-1 of the three groups were detected and compared.Results The levels of CD62P,CD63 and ET-1 of diabetic nephropathy group were(8.21±2.45)%,(15.68±3.36)%and(2.83±1.05)pg/ml,which were all higher than(5.56±2.32)%,(7.61±2.17)%and(2.31±0.37)pg/ml of non-diabetic nephropathy group,and the difference was statistically significant(P<0.05).The levels of CD62P,CD63 and ET-1 of diabetic nephropathy group were all higher than those of healthy control group,and the difference was statistically significant(P<0.05).The levels of CD62P,CD63 and ET-1 of non-diabetic nephropathy group were all higher than those of healthy control group,and the difference was statistically significant(P<0.05).Conclusion The expressions of platelet activation markers CD62P,CD63 and ET-1 in patients with diabetic nephropathy are all high,which can be treated clinically with antiplatelet activation drugs,which can provide an important basis for the follow-up treatment of diabetic nephropathy and is worthy of further study.