巨噬细胞调控伤口愈合研究进展

Research progress on the involvement and regulation of macrophages in wound healing

目的综述巨噬细胞在伤口愈合中的调控作用研究进展。方法通过检索国内外相关文献44篇,着重介绍巨噬细胞的个体发育、来源、表型异质性以及巨噬细胞在伤口愈合过程中所扮演的生物学作用。我们也介绍了一些基因学、药理学和生物工程学方法,通过干预巨噬细胞表型和功能来促进伤口愈合。结果伤口愈合是一个复杂的生物学过程,由四个连续又相互交错的时期组成。巨噬细胞在伤口愈合的不同时期和组织再生过程中扮演着重要作用。结论由于巨噬细胞在伤口愈合不同时期所扮演的重要作用,可作为一个潜在靶点,通过干预巨噬细胞表型和功能,开发一些新颖的临床治疗药物。

Objective To review the research progress on the involvement and regulation of macrophages in wound healing.Methods The paper described the ontogeny,origin and phenotypical heterogeneity and the crucial biological function of macrophages in wound healing based on 44 domestic and foreign literatures.Meanwhile,the paper introduced some genetic,pharmacologic and bioengineering methods for regulating macrophage phenotype and functions and accelerating wound repair.Results Wound healing was a complicated biological process,consisting of four continuous and interlaced phases.Macrophages played an important role in different phases and tissue regeneration of wound healing.Conclusion As macrophage plays key roles in each period of wound healing,it can be served as a potential target to develop novel clinical drugs by regulating the phenotype and function of macrophages.