摘要
氯胺酮在麻醉方面的作用与机制已经被广泛研究和报道。近年研究发现,氯胺酮与炎症反应密切相关,可作为炎症反应和应激诱导免疫紊乱的一种调节剂,在炎症相关疾病的发生、发展中具有正负调节作用。文章主要针对氯胺酮在脓毒症及炎症性疾病中的抗炎、促炎作用及机制进行综述,为氯胺酮的临床转化应用提供新的靶点、方法和策略。
The role and mechanism of ketamine in anesthesia have been widely studied and reported.Recent studies have found that ketamine is closely associated with inflammation,which can be used as a regulator of inflammatory response and stress‑induced immune disorder and takes a positive or negative regulatory role in the pathogenesis of inflammation‑related diseases.The current review focuses on the anti‑inflammatory and pro‑inflammatory effects and mechanisms of ketamine in sepsis and inflammatory diseases,so as to provide new targets,methods and strategies for the use of ketamine in medical practice.
作者
王璐
李志勤
张露
吴黄辉
李春晖
龚毅
侯立朝
邓斌
Wang Lu;Li Zhiqin;Zhang Lu;Wu Huanghui;Li Chunhui;Gong Yi;Hou Lichao;Deng Bin(Department of Anesthesiology,Xiang'an Hospital of Xiamen University,Xiamen 361101,China)
出处
《国际麻醉学与复苏杂志》
CAS
2021年第4期440-443,共4页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81501207)
厦门市科技局医疗卫生科技计划项目(3502Z20194046)
中央高校基本科研业务费专项资金(20720200037)
细胞应激生物学国家重点实验室(厦门大学)开放课题基金(SKLCSB2019KF015)
厦门大学校长基金(20720170106)
福建省海峡医药卫生交流协会重点科研项目(2020HYH10)。
关键词
氯胺酮
免疫调节
炎症反应
脓毒症
中枢神经系统
Ketamine
Immunoregulation
Inflammatory response
Sepsis
Central nervous system
