摘要
[目的]观察不同剂量及不同口服频次艾司奥美拉唑肠溶片治疗幽门螺杆菌(Hp)阴性胃术后吻合口溃疡临床效果和安全性。[方法]选取在我院诊断Hp阴性胃术后吻合口溃疡84例,按随机数字表法分为甲组和乙组,每组42例。2组均口服艾司奥林拉唑肠溶片(阿斯利康制药有限公司生产,国药准字H20046379),疗程均4周。甲组40 mg/次,1次/d(晨起);乙组20 mg/次,2次/d(晨起+睡前)。对2组患者的临床症状缓解率和胃镜下溃疡愈合率进行分析对比。[结果]乙组治疗近期腹痛临床症状缓解率优于甲组(P<0.01),2组远期效果相当(P>0.05)。胃镜观察溃疡愈合情况,2组有效率相同,差异无统计学意义(P>0.05)。[结论]艾司奥美拉唑肠溶片治疗Hp阴性胃术后吻合口溃疡具有明显的疗效,且艾司奥美拉唑肠溶片20 mg,2次/d近期对临床症状缓解有效率高于艾司奥美拉唑肠溶片40 mg,1次/d。
[Objective]To observe the clinical effect and safety of esomeprazole enteric-coated tablets in different doses and oral frequency in the treatment of anastomotic ulcers after Helicobacter pylori(Hp)-negative gastric surgery.[Methods]A total of 84 cases of anastomotic ulcers after Hp-negative gastric surgery were diagnosed in our hospital from February 2016 to August 2020.They were divided into group A and group B according to a random number table,with 42 cases in each group.Esomeprazole enteric-coated tablets(manufactured by AstraZeneca Pharmaceutical Co.,Ltd.,National Medicine Zhunzi H20046379)were taken orally in both groups,and esomeprazole enteric-coated tablets 40 mg/time,1 time/d(morning Beginning),the course of treatment was 4 weeks.Group B takes orally esomeprazole enteric-coated tablets 20 mg/time,2 times/d(morning+before going to bed),treatment course is 4 weeks.The clinical symptom relief rate and gastroscopic ulcer healing rate of the two groups were analyzed and compared.[Results]Esomeprazole enteric-coated tablets 20 mg,2 times/d,in the treatment of short-term abdominal pain,the clinical symptom relief rate was better than esomeprazole enteric-coated tablets 40 mg,1 time/d,and the long-term effect was equivalent.Observing the healing of ulcers under gastroscopy,the two groups had the same effective rate,and the difference was not statistically significant.[Conclusion]Esomeprazole enteric-coated tablets have obvious curative effect in the treatment of anastomotic ulcers after Hp-negative gastric surgery,and esomeprazole enteric-coated tablets 20 mg,2 times/d,have a higher effective rate of clinical symptom relief in the near future esomeprazole enteric-coated tablets 40 mg,once daily.It provides a theoretical basis for the further.
作者
张昌欨
彭波
ZHANG Chang-xu;PENG Bo(Department of Gastroenterology,Optics Valley Branch,Wuhan Third Hospital,430073 Wuhan,China)
出处
《临床消化病杂志》
CAS
2021年第2期99-101,共3页
Chinese Journal of Clinical Gastroenterology
基金
武汉市卫健委临床医学科研项目(No:WZ17Z06)。
关键词
吻合口溃疡
艾司奥美拉唑肠溶片
疗效观察
esomeprazole enteric coated tablets
anastomotic ulcer
curative effect observation