摘要
2009年首次在德国的褐家鼠中检测到戊型肝炎病毒,称为鼠戊型肝炎病毒(鼠HEV)。目前已在许多国家和地区的啮齿目等动物中检测到鼠HEV。由于鼠HEV与已知人源HEV基因序列同源性较低,一直认为其感染人类的可能性小,从而被忽略。最近先后报道了鼠HEV感染人引起慢性及急性戊型肝炎的病例,引起关注。本文对鼠HEV在动物中的流行及对人类感染情况的研究进展进行综述。
In 2009,hepatitis E virus was first detected in wild rats(Rattus norvegicus)in Germany and was designated as rat hepatitis E virus(rat HEV).Since then,rat HEV has been detected in various murine rodents in many geographic regions.The potential of rat HEV to infect human has been ignored as the viral genomic nucleotide sequences of rat HEV and the HEV strains of human sources are only about 50%-56%identical.Recently,a few clinical hepatitis E cases with chronic or acute rat HEV infection have been reported and raised many concerns.Here,advances in studies of the prevalence of rat HEV in animals and the clinical hepatitis E cases caused by rat HEV were reviewed.
作者
耿彦生
朱泓宇
王佑春
Geng Yansheng;Zhu Hongyu;Wang Youchun(College of Public Health,Hebei University,Baoding 071000,China;Division of HIV/AIDS and Sex-transmitted Virus Vaccines,National Institutes for Food and Drug Control,Beijing 102629,China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2021年第4期318-321,共4页
Chinese Journal of Microbiology and Immunology
基金
国家自然科学基金(81371830)
河北省高等学校科学技术研究项目(ZD2018229)。
