血小板功能分析仪-100测定代谢综合征患者血小板功能及其影响因素分析

Assessment of platelet function using a Platelet Function Analyzer-100 for metabolic syndrome patients

目的评估代谢综合征(MS)患者的血小板功能,并探讨血小板过度活化的相关因素。方法对2018年1月至12月在首都医科大学附属北京友谊医院国际医疗中心进行体检的人员血栓形成的速度,即闭合时间(CT)。应用SPSS 21.0软件进行统计分析,采用病例对照的研究方法,应用血小板功能分析仪PFA-100测定体外血小板。根据纳排标准共纳入999例研究对象,按MS诊断标准将研究对象分为MS组(501例)和对照组(498例)。结果MS组CT值[(106.6±27.8)s]明显低于对照组[(113.7±27.9)s],差异有统计学意义(t=2.7,P=0.002)。CT值≤111.2 s组BMI、WC、高血压患病人数、TC、TG、LDL-C、UA以及PLR显著高于CT值>111.2 s组,提示BMI、腰围、高血压、TC、TG、LDL-C、血尿酸以及PLR与CT值呈负相关(统计值分别为-3.0,-2.5,6.2,-2.0,-3.7,-1.9,-2.6,-2.2,均P<0.05)。结论本研究采用PFA-100测定MS患者的血小板功能,证实MS患者存在血小板过度活化,与BMI、腰围、血压、血脂、尿酸和PLR升高有关。

Objective Metabolic syndrome(MS)patients and determine factors related to platelet hyperactivation.Methods A total of 999 participants(822 males and 177 females)were enrolled.Participants were divided into two groups according to the metabolic index:MS group(501)and normal control(NC)group(498).Platelet function was tested with PFA100(Siemens USA,Deerfield,Illinois)which measures the time it takes for blood to occlude an aperture(closure time,CT)following stimulation with collagen and adenosine diphosphate.Statistical analyses were performed using the SPSS statistical software package,version 22.0(IBM Corporation,Armonk,NY,USA).Results MS group had significantly shorter CT values compared with NC group(106.6±27.8s)vs(113.7±27.9s).Higher BMI,WC,BP,TC,TG,LDL-C,UA,and PRL were correlated with shorter CT values(all P<0.05).Conclusion Our results indicated platelet hyperactivation exists in MS which was related to obesity and elevated blood pressure,blood lipids,uric acid,and PLR.