miRNA在胰岛素信号传导通路中的作用研究

Research of miRNA in insulin signaling pathway

2型糖尿病是临床上常见的一种代谢紊乱相关疾病,胰岛素抵抗作为2型糖尿病的重要发病因素之一,与胰岛素信号传导通路密切相关。微小RNA(microRNA,miRNA)是一类非编码小分子RNA,通过与靶基因结合在转录后水平调节蛋白的表达,参与多种病理生理过程。现有研究显示,miRNA参与胰岛素信号传导通路的调控,本文综述了部分调控胰岛素信号传导通路中关键蛋白表达的miRNA,及它们对2型糖尿病胰岛素抵抗的调节机制,为探寻2型糖尿病的诊断及治疗提供了新的方向。

Type 2 diabetes(T2DM)is a common metabolic disorder-related disease. Insulin resistance,one of the significant pathogenesis factors of T2DM,is tightly related to the insulin signaling pathway. MicroRNA(miRNA),is a small non-coding RNA,modulates protein expression at the post-transcriptional level through binding with target genes,which participates in avariety of pathophysiological processes. Previous studies reported that miRNA palys important roles in the regulation of insulin signaling pathway. This article reviewed some miRNAs affecting key proteins in insulin signaling pathway and the regulation mechanism of the miRNAs in T2DM-associated insulin resistance to provide a new direction for the pathogenesis and treatment of T2DM.