α-氯醛糖和右美托咪定对貂的口服麻醉效果观察

Observation of anesthetic effects of oral administration of α-chloroaldose and dexmedetomidine in mink

将α-氯醛糖与右美托咪定复合使用,对10只健康成年咖啡貂实施口服麻醉,并对麻醉过程中貂的常规生理指标、麻醉时间、麻醉作用效果及生物反射等实施连续监测,以观察2种药物复合使用后麻醉时期对机体主要生理机能干扰和麻醉四要素等,综合评估其口服麻醉效果。结果:貂口服麻醉后体温连续下降,至监测结束时(口服药物后60 min),貂的体温下降了1.4℃。麻醉全过程脉搏血氧饱和度、呼吸频率和心率均表现出先降低后升高的变化趋势,其中呼吸频率和心率在口服药物后50 min时下降最为明显;麻醉期呈现出诱导平稳、维持时间适宜、苏醒迅速的特点;镇静、镇痛及肌松效果确实且均衡,可提供约30 min良好的麻醉作用时间;角膜、眼睑及肛门生物反射等在麻醉过程中始终存在,在口服给药后的20~50 min受到中等程度的抑制,体现出较为适宜的麻醉深度。

In this study, oral anesthesia was administered to 10 healthy adult coffee minks using a combination of α-chloroaldose and dexmedetomidine. In order to evaluate the anesthesia period after the combined use of the two drugs, the interference in the main physiological function of the body and the four elements of anesthesia, and to comprehensively evaluate the oral anesthesia effect, the routine physiological indexes, anesthesia time, anesthesia effect and biological reflex of minks were monitored continuously in the process of anesthesia. The results showed that the body temperature of the minks decreased continuously, by 1.4 ℃, after oral anesthesia until the end of monitoring(60 min after oral anesthesia). The saturation of pulse oximetry, respiratory rate and heart rate of the animals all showed a trend of decreasing first and then increasing in the whole anesthesia process, and their respiratory rate and heart rate decreased most obviously 50 min after the oral administration. The anesthesia period was characterized by stable induction, appropriate maintenance time and rapid recovery. The effects of sedation, analgesia and muscle relaxation were definite and balanced, providing a good duration of action of about 30 min. Corneal, eyelid and anal biological reflexes were consistently present during anesthesia, which were moderately inhibited at 20-50 min after the oral administration, showing a more appropriate depth of anesthesia.