α-磷酸三钙/α-半水硫酸钙复合骨水泥的制备及力载荷下的性能研究

Preparation and mechanical properties ofα-tricalciumphosphate/α-calcium sulfate hemihydrate composite bone cement

α-磷酸三钙(α-tricalcium phosphate,α-TCP)是目前临床上理想的骨修复材料之一,其生物相容性良好且降解产物对人体无害,但力学强度较低。Wolf提出,人体骨骼在长时间接受外力时,会增大骨密度与坚硬强度,研究力载荷下材料的性能具有重要意义。研究以α-TCP为主,与α-半水硫酸钙(α-calcium sulfate hemihydrate,α-CSH)复合制备α-TCP/α-CSH(α-TCP占质量比为100%、95%、90%、85%、80%、75%),并模拟人骨受力状态,对其凝固时间、静态力学性能、动态力学性能、降解性能以及生物相容性进行了研究。结果表明:α-TCP质量比占95%的复合骨水泥材料其凝固时间为7 min;静态加载时抗压强度也为最大,对其进行动态循环加载,所能承受的峰值力最大;在降解过程中其降解率为负值,水化效果明显。认为α-磷酸三钙占比为95%的复合骨水泥材料性能较优,为该材料的临床应用研究提供理论实验依据。

α-tricalcium phosphate(α-TCP)is currently one of the ideal bone repair materials in clinical practice.It has good bio-compatibility and its degradation products are harmless to people,but its mechanical strength is low.Wolf proposed that human bones will increase bone density and rigidity when they receive external force for a long time.It is of great significance to study the properties of materials under loads.This research combinesα-TCP andα-calcium sulfate hemihydrate(α-CSH)to prepareα-TCP/α-CSH(α-TCP accounts for 100%,95%,90%,85%,80%,75%),simulates the force state of human bone,and studies its solidification time,static mechanical properties,dynamic mechanical properties,degradation properties and bio-compatibility.The results show that the composite bone cement material with 95%of theα-TCP mass ratio has a setting time of 7 min.The compressive strength is also the largest under static loading,and the peak force that it can withstand is the largest when subjected to dynamic cyclic loading.In the process,the degradation rate is negative and the hydration effect is obvious.It is believed that the composite bone cement material with 95%ofα-tricalcium phosphate has better performance,which provides theoretical experimental basis for the clinical application of this material.