阿托伐他汀钙片联合钻孔引流术对慢性硬膜下血肿患者炎性指标的影响与安全性分析

Effect and safety analysis of atorvastatin calcium tablet combined with drilling and drainage on inflammatory indexes in patients with chronic subdural hematoma

目的分析阿托伐他汀钙片联合钻孔引流术对慢性硬膜下血肿(CSDH)患者炎性指标的影响与安全性。方法选取无锡市新吴区新瑞医院2018年2月至2020年2月收治的74例CSDH患者,根据随机数字表法将患者分为对照组(37例,行钻孔引流术治疗)与观察组(37例,行钻孔引流术联合阿托伐他汀钙片治疗)。对比两组患者治疗3个月后的临床疗效;对比两组患者治疗前与治疗3个月后的WHO生存质量评估简表(WHOQOL-BREF)、卡氏功能状态评分(KPS)及炎性因子水平变化;对比两组患者治疗3个月后的并发症发生情况。结果治疗3个月后观察组患者临床总有效率高于对照组;相较于治疗前,治疗3个月后两组患者KPS评分与WHOQOL-BREF评分均升高,且观察组高于对照组,而治疗3个月后两组患者血清C-反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)水平均降低,且观察组低于对照组;治疗期间观察组患者并发症总发生率低于对照组(均P<0.05)。结论给予CSDH患者钻孔引流术后联合阿托伐他汀钙治疗,可明显提高治疗效果,减轻炎症反应,降低血肿复发率,提高患者的生活自理能力,且安全性较高。

Objective To analyze the effect and safety of atorvastatin calcium tablets combined with drilling and drainage on inflammatory indexes in patients with chronic subdural hematoma(CSDH).Methods 74 cases of CSDH patients admitted to Wuxi Branch of Ruijin Hospital from February 2018 to February 2020 were selected,according to the random number table method,the patients were divided into control group(37 cases,treated with drilling and drainage)and observation group(37 cases,treated with drilling and drainage combined with atorvastatin calcium tablets).the clinical efficacy of the two groups was compared after 3 months of treatment;The changes of WHO quality of life assessment instrument(WHOQOL-BREF),KPS score and inflammatory factors before treatment and 3 months after treatment were compared between the two groups;The incidence of complications after 3 months of treatment was compared between the two groups.Results After 3 months of treatment,the total clinical effective rate of the observation group was higher than that of the control group;compared with before treatment,the KPS score and WHOQOL-BREF score of the two groups of patients increased after 3 months of treatment,and the observation group was higher than the control group;the levels of serum C-reactive protein(CRP),interleukin-6(IL-6)and interleukin-8(IL-8)decreased,and the observation group was lower than the control group;during the treatment,the total incidence of complications in the observation group was lower than that in the control group(all P<0.05).Conclusion The combination of atorvastatin calcium treatment after drilling and drainage of CSDH patients can significantly improve the treatment effect,reduce inflammation,reduce the recurrence rate of hematoma,improve the patient's ability to take care of themselves,with high safety.