诺氏评估量表在注射用丹参多酚酸盐不良反应评价中的作用

Function of Naranjo's assessment scale in the evaluation of adverse reactions of salvianolic acid polyphenols for injection

目的以注射用丹参多酚酸盐诱发的不良反应为例,介绍并阐述诺氏(Naranjo's)评估量表在药物不良反应评价中的作用。方法应用诺氏(Naranjo's)评估量表评价1例注射用丹参多酚酸盐联用西格列汀二甲双胍致大面积皮肤红疹的相关性,分析其诱发不良反应的机制及应对措施。结果应用丹参多酚酸盐第6天突发皮肤红疹,立即停用,并予抗过敏对症处理;第7天皮疹面积扩大至前胸后背、双上肢和双大腿。继续抗过敏治疗,后未再发皮疹,并于停药后第4天好转;诺氏量表评分为3分,评定为可能有关。结论丹参多酚酸盐致皮肤红疹后应立即停药,对症治疗。事前询问相关过敏史,采用科学的手段排除并确认发病原因,提高服务临床的能力。

Objective To introduce and expound the function of Naranjo's assessment scale in the adverse reactions(ADRs)by taking the ADRs induced by salvianolic acid polyphenols for injection as an example.Methods The Naranjo's assessment scale was used to evaluate the correlation of a large area skin rash caused by salvianolic acid polyphenols for injection combined with sitagliptin metformin,and the mechanism of ADRs and countermeasures were analyzed.Results On the 6th day after application of salvianolic acid polyphenols,skin rash broke out.The drug was stopped immediately,and the patient was given anti-allergic symptomatic treatment.On the 7th day,the rash spread to the chest,back,upper limbs and thighs.After continuing anti-allergic treatment,there was no rash again,and the symptom was improved on the 4th day after stopping the drug.The score of Naranjo's assessment scale was 3 points,which was assessed as possibly related.Conclusion After skin rash is caused by salvianolic acid polyphenols,the drug must be stopped immediately,and symptomatic treatment should be given.The related allergy history should be inquired in advance,scientific countermeasures should be applied to eliminate and confirm the cause of the disease,and the ability of clinical service shoul d be improved.