生长抑素在重症急性胰腺炎治疗中的应用

The application of somatostatin in the treatment of severe acute pancreatitis

目的探讨重症急性胰腺炎患者采用生长抑素治疗的效果及对并发症概率的影响。方法选择2015年1月至2020年6月本院收治的90例重症急性胰腺炎患者为研究对象,随机平均分成两组,对照组(n=45,予以泮托拉唑钠)与观察组(n=45,联合生长抑素),对比两组患者的各项症状及体征恢复具体时间、患者血清炎性因子水平的测量结果及出现并发症的概率。结果与对照组比较,观察组腹痛症状在更短时间内缓解、体温、血淀粉酶及肠道功能在更短时间恢复正常,患者更快出院(P<0.05);观察组治疗后血清炎性因子水平显著低于治疗前,且组间比较下降幅度大于对照组(P<0.05);观察组并发症发生率显著低于对照组(8.89%vs.31.11%)(P<0.05)。结论重症急性胰腺炎患者给予生长抑素治疗后,其常见症状可在短时间内缓解或恢复正常,且炎性因子水平也得以降低,其安全性也有所保障,具有显著的临床使用及推广价值。

Objective To investigate the effect of somatostatin in the treatment of severe acute pancreatitis and its influence on the probability of complications.Methods A total of 90 patients with severe acute pancreatitis admitted to our hospital from January 2015 to June 2020 were randomly divided into two groups,the control group(n=45,given pantoprazole sodium)and the observation group(n=45,combined with somatostatin).The recovery time of symptoms and signs,the measurement results of serum inflammatory factors and the probability of complications were compared between the two groups.Results The duration of abdominal pain symptoms,the time of recovery of body temperature,serum amylase and intestinal function and the hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum inflammatory factors of the two groups of patients were significantly lower than those before treatment,and the decrease of the levels of serum inflammatory factors in the observation group was greater than that in the control group,with statistically significant differences(P<0.05).The incidence of complications in the observation group was 8.89%,which was lower than 31.11%in the control group,and the difference was statistically insignificant(P<0.05).Conclusion When the patients with severe acute pancreatitis take somatostatin,their abdominal pain symptoms can be relieved in a short time,and their body temperature,serum amylase and intestinal function can recover in a short time.It shortens the hospitalization time for the patients,reduces the levels of serum inflammatory factors and incurs few complications.As an effective and safe therapy,it is worthy of promotion.