音乐疗法对老年期痴呆患者认知功能干预效果的Meta分析

Effectiveness of music therapy on cognitive function of the elderly with dementia:a meta-analysis

目的评价音乐疗法对老年期痴呆患者认知功能的干预效果。方法检索国内外数据库自建库至2020年7月12日公开发表的有关音乐疗法对老年期痴呆患者认知功能干预效果的随机对照试验,符合质量标准的文献采用RevMan5.3软件进行分析。结果纳入15项随机对照试验,共1101例研究对象。Meta分析结果显示,与常规对照组相比,音乐干预能够改善老年期痴呆患者的认知功能[MD=1.58,95%CI(0.54,2.62),P<0.01]。亚组分析显示,干预疗程≥12周[MD=1.75,95%CI(0.61,2.90),P<0.01]、被动音乐干预[MD=2.27,95%CI(0.45,4.09),P<0.05]、主动+被动音乐干预[MD=2.32,95%CI(0.02,4.63),P<0.05]、团体干预[MD=1.65,95%CI(0.39,2.92),P<0.05]、干预频率≥2次/周[MD=1.50,95%CI(0.29,2.70,P<0.05]、干预总时长≥30 h[MD=1.66,95%CI(0.21,3.10),P<0.05]对老年期痴呆患者认知功能的影响效果较为显著。结论音乐疗法对老年期痴呆患者认知功能有显著效果,建议使用音乐干预时,采用团体干预形式,以被动音乐干预为主,每周至少2次,总干预时间至少30 h。因纳入文献样本量及质量限制,本结论还需更多大样本、高质量的随机对照试验进一步验证。

Objective To evaluate the effectiveness of music therapy on cognitive function of elderly patients with dementia.Methods Electronic databases were searched from inception to 12th July,2020,to retrieve randomized controlled trials(RCTs)concerning the effect of music therapy on cognitive function of the elderly with dementia.After data extraction and quality evaluation of the literature,a meta-analysis of the included studies was performed through RevMan5.3 version.Results Fifteen RCTs were included,involving 1101 samples.Meta-analysis showed that music intervention could improve cognitive function of older persons with dementia[MD=1.58,95%CI(0.54,2.62),P<0.01].Subgroup analysis showed that intervention course≥12 weeks[MD=1.75,95%CI(0.61,2.90),P<0.01],passive music intervention[MD=2.27,95%CI(0.45,4.09),P<0.05],active and passive music intervention[MD=2.32,95%CI(0.02,4.63),P<0.05],group intervention[MD=1.65,95%CI(0.39,2.92),P<0.05],the frequency of intervention≥twice a week[MD=1.50,95%CI(0.29,2.70),P<0.05],and the total duration≥30 hours[MD=1.66,95%CI(0.21,3.10),P<0.05]had significant effects.Conclusion Music therapy has a significant effect on cognitive function of older persons with dementia.Passive and group-based music therapy provided twice a week and greater than 30 hours is recommended.Because of limited number and quality of the studies included in the meta-analysis,the conclusion needs to be further verified by more large-sample and high-quality RCTs.