抗磷脂抗体综合征相关性复发性流产的研究进展

Research progress of antiphospholipid antibody syndromerelated recurrent abortion

抗磷脂抗体综合征是以抗磷脂抗体介导的,以动静脉血栓形成、病态妊娠或血小板减少为临床表现的一系列综合征,疾病表现涉及全身多系统、多器官,同时也是需要妇产科、风湿免疫科、中医科、血液科等共同管理的多学科疾病。抗磷脂抗体综合征最常见的产科并发症是不良妊娠,主要表现为复发性流产、子痫前期、胎儿生长受限、早产等。对妊娠合并抗磷脂抗体综合征的患者早诊断,早治疗,可有效减少不良母胎妊娠结局。本文主要对抗磷脂抗体综合征在复发性流产的诊疗作一综述。

Antiphospholipid antibody syndrome is a series of syndromes mediated by antiphospholipid antibody and featured by arteriovenous thrombosis,morbid pregnancy or thrombocytopenia.The disease manifestations involve multiple systems and organs of the whole body,and it is also a multidisciplinary disease that needs to be managed by departments of obstetrics and gynecology,rheumatology and immunology,traditional Chinese medicine,hematology,etc.The most common obstetric complication of antiphospholipid syndrome is adverse pregnancy,which is mainly manifested as recurrent abortion,preeclampsia,fetal growth restriction,premature birth,etc.Early diagnosis and treatment of pregnant women complicated with antiphospholipid antibodies can effectively reduce the adverse maternal and fetal pregnancy outcomes.The diagnosis and treatment of antiphospholipid antibody syndrome in recurrent abortion were mainly reviewed in this paper.