蝾螈肢体再生中终末分化细胞去分化调控机制的研究进展

Progress of mechanisms regulating dedifferentiation of terminally differentiated cells during salamander limb regeneration

两栖类有尾目动物蝾螈具有极强的再生能力,尤其在肢体受损被截断后能在较短时间内达到复原,而哺乳动物不具备肢体再生的能力。在肢体再生中,残肢处的终末分化细胞发生去分化是诱导再生芽基形成,启动断肢再生的重要始动步骤。现从蝾螈断肢再生的组织形态、细胞生物学、信号分子和神经免疫调控等方面对终末分化细胞去分化调控机制的进展进行综述,为肢体再生医学的研究提供借鉴。

Urodele amphibians(salamander)exhibit superior regeneration ability that mammals don’t possess,especially their limbs can achieve full recovery within a relatively short period of time after amputation.Dedifferentiation of the terminally differentiated cells into blastema cells is considered to be critical in inducing blastema formation and initiating limb regeneration response.This review recapitulated the current progress of investigating regulatory mechanisms of dedifferentiation during salamander limb regeneration,in aspects of histology,cell biology,molecular signaling,neural and immuno regulation,thus shedding light on future research of regeneration medicine.