沙门氏菌Ⅰ型菌毛研究进展

The research progress of Salmonella typeⅠfimbriae

据WHO估计,全球每年有数十亿人患食源性疾病,其中由沙门氏菌感染引起的死亡就超过23万人。在沙门氏菌众多的毒力因子中,菌毛在该病原体感染过程中发挥了不可或缺的作用。菌毛(又称纤毛)是细菌表面的丝状蛋白附属物,是细菌对宿主细胞产生作用和造成感染的关键因子。其中,Ⅰ型菌毛是肠杆菌科成员(包括沙门氏菌)中最常见的菌毛之一,对于细菌启动和发挥致病作用至关重要。鉴于Ⅰ型菌毛对沙门氏菌的重要性,现就沙门氏菌Ⅰ型菌毛的结构、表达调控、致病性及其与其他毒力因子的相互作用等方面展开讨论,旨在为靶向Ⅰ型菌毛来研究沙门氏菌的致病机理提供一定的理论参考。

Based on the data from WHO,billions of people worldwide suffer from foodborne diseases each year,of which 230000 die from Salmonella infection.Among Salmonella virulent factors,fimbriae play a significant role in Salmonella-related infection.Fimbriae(also known as cilium)are a kind of filamentous protein presenting on bacterial surface,which are responsible for bacteria-host interaction and infection.As one of the most common fimbriae in enterobacteriaceae(including Salmonella),typeⅠfimbriae are crucial to initial attachment and pathogenic infection of bacteria.Considering the importance of Salmonella typeⅠfimbriae,this review mainly focused on the structure,expression regulation,interactions with other virulent factors and pathogenicity of typeⅠfimbriae.The aim of this review is to provide a systematic theoretical reference for targeting typeⅠfimbriae to explore the pathogenic mechanism of Salmonella.