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半夏泻心汤对糖尿病小鼠糖脂代谢及胰岛素分泌的影响 被引量:8

Effects of Banxia Xiexin Decoction on glucose and lipid metabolism and insulin secretion in diabetic mice
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摘要 目的探讨半夏泻心汤对糖尿病小鼠糖脂代谢及胰岛素分泌的影响。方法 8周龄SPF级雄性C57BL/6小鼠高脂饲料联合链脲佐菌素(streptozocin, STZ)腹腔注射造模,分为对照组、模型组、二甲双胍组及半夏泻心汤低、中、高剂量组共6组,分别给予相应的液体连续灌胃7周,灌胃结束后检测各组体重、空腹血糖、糖化血红蛋白、脏器指数、血脂四项以及空腹胰岛素水平的变化。结果半夏泻心汤不同剂量组空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均显著降低(P<0.05),空腹胰岛素、高密度脂蛋白胆固醇水平均提高(P<0.05),其中以半夏泻心汤中、高剂量组效果更佳。结论半夏泻心汤具有显著改善糖尿病小鼠糖脂代谢、促进胰岛素分泌的作用,可用于临床糖尿病的治疗,但其作用机制有待进一步探讨。 Objective To investigate the effect of Banxia Xiexin Decoction on glucose and lipid metabolism and insulin secretion in diabetic mice.Methods 8-week-old SPF male C57 BL/6 mice with high-fat diet combined with STZ intraperitoneal injection were used to create models, and they were divided into control group, model group, metformin group, and Banxia Xiexin Decoction low, medium and high dose groups.After 7 weeks of intragastric administration with corresponding liquids, the changes of body weight, fasting blood glucose, glycosylated hemoglobin, organ index, blood lipids and fasting insulin levels were observed in each group.Results In different dosage groups of Banxia Xiexin Decoction, fasting blood glucose, glycosylated hemoglobin, triglycerides, total cholesterol, low-density lipoprotein cholesterol levels were significantly reduced(P<0.05),and fasting insulin and high-density lipoprotein cholesterol increased(P<0.05).Among them, the middle and high dose groups of Banxia Xiexin Decoction had better effect.Conclusion Banxia Xiexin Decoction can significantly improve glucose and lipid metabolism and promote insulin secretion in diabetic mice.It can be used for the clinical treatment of diabetes, but its mechanism needs to be further explored.
作者 杜立娟 吴倩 倪青 DU Li-juan;WU Qian;NI Qing(Endocrinology Department of Guanganmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处 《北京中医药》 2021年第3期246-249,共4页 Beijing Journal of Traditional Chinese Medicine
基金 国家自然科学基金项目(81373594)。
关键词 半夏泻心汤 糖尿病 糖脂代谢 胰岛素 Banxia Xiexin Decoction diabetes glucose and lipid metabolism insulin
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