利培酮联合奥氮平治疗首发精神分裂症伴肥胖患者的效果

Effects of Risperidone combined with Olanzapine in treatment of first-episode schizophrenia with obesity

目的:观察利培酮联合奥氮平治疗首发精神分裂症伴肥胖患者的效果。方法:选取102例首发精神分裂症伴肥胖患者作为研究对象,按随机数字表法分为对照组和研究组各51例。对照组采用利培酮治疗,研究组在对照组基础上联合奥氮平治疗,比较两组临床疗效,治疗前后阳性与阴性症状量表(PANSS)评分,以及治疗前后血糖、血脂、催乳素(PRL)和瘦素(LP)水平。结果:研究组治疗总有效率为94.12%(48/51),高于对照组的78.43%(40/51),差异有统计学意义(P<0.05);治疗后,研究组PANSS评分低于对照组,空腹血糖、餐后2 h血糖、总胆固醇、低密度脂蛋白胆固醇、PRL和LP水平均高于对照组,差异有统计学意义(P<0.05)。结论:奥氮平联合利培酮治疗首发精神分裂症伴肥胖患者可提高治疗总有效率,降低PANSS评分,效果优于单纯利培酮治疗,但会造成血糖、血脂、PRL、LP水平升高。

Objective:To explore effects of Risperidone combined with Olanzapine in treatment of first-episode schizophrenia with obesity.Methods:102 patients with first-onset schizophrenia and obesity were selected as the research objects,and were divided into control group and study group according to the random number table,51 cases in each.The control group was treated with Risperidone,while the study group was treated with Olanzapine on the basis of that of the control group.The clinical efficacy,the positive and negative syndrome scale(PANSS)scores before and after the treatment,and the levels of blood glucose,blood lipids,prolactin(PRL)and leptin(LP)were compared between the two groups.Results:The effective rate of treatment in the study group was 94.12%(48/51),which was higher than 78.43%(40/51)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the PANSS score of the study group was lower than that of the control group;the levels of fasting blood glucose,2 h postprandial blood glucose,total cholesterol,low-density lipoprotein cholesterol,PRL and LP were higher than those of the control group;and the differences were statistically significant(P<0.05).Conclusions:Olanzapine combined with Risperidone in the treatment of the patients with first-episode schizophrenia with obesity can increase the effective rate of treatment,reduce the PANSS score,and significantly increase the levels of blood sugar,blood lipids,PRL,and LP.Moreover,it is superior to single Risperidone.