柴胡疏肝散联合雷贝拉唑治疗肝胃郁热型反流性食管炎患者的效果

Effects of Chaihu Shugan powder combined with Rabeprazole in treatment of reflux esophagitis of liver-stomach stagnation heat type

目的:探讨柴胡疏肝散联合雷贝拉唑治疗肝胃郁热型反流性食管炎(RE)患者的效果。方法:回顾性分析2018—2019年该院收治的100例肝胃郁热型RE患者的临床资料,依据治疗方案不同分为对照组和观察组各50例。对照组给予雷贝拉唑钠肠溶片治疗,观察组在对照组基础上联合柴胡疏肝散治疗,比较两组临床疗效、治疗前后中医证候积分及不良反应发生率。结果:观察组治疗总有效率为98.00%,高于对照组的68.00%,差异有统计学意义(P<0.05);治疗后,两组胸痛、嗳气、反酸证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:柴胡疏肝散联合雷贝拉唑治疗肝胃郁热型RE患者效果显著,能够促进临床症状缓解,降低中医证候积分,效果优于单用雷贝拉唑。

Objective:To investigate effects of Chaihu Shugan powder combined with Rabeprazole in treatment of reflux esophagitis(RE)of liver-stomach stagnation heat type.Methods:A retrospective analysis of the clinical data of 100 RE patients of liver-stomach stagnation heat type admitted to the hospital from January 2018 to December 2019 was performed.According to different treatment plans,these patients were divided into control group and observation group,each with 50 cases.The control group was treated with Rabeprazole sodium enteric-coated tablets,while the observation group was treated with Chaihu Shugan powder on the basis of those of the control group.The clinical efficacy,the TCM syndrome scores before and after the treatment and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 98.00%,which was higher than 68.00%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the TCM syndrome scores such as chest pain,belching,and acid reflux in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Chaihu Shugan powder combined with Rabeprazole has a significant effect in the treatment of RE of liver-stomach stagnation heat type,which can promote the clinical symptom relief and reduce the TCM syndrome scores.Moreover,it is superior to single Rabeprazole.