摘要
探讨端粒酶逆转录酶(TERT)在心肌缺血再灌注损伤(MIRI)过程中的保护作用及机制。关于TERT在MIRI中作用机制的相关研究并进行综合分析,表明TERT在MIRI中发挥重要作用,其主要的保护作用包括调节细胞增殖及凋亡、调节血管再生、调节线粒体功能等。本文就TERT在MIRI中发挥保护作用方面进行综述,并探讨其作用机制,将有助于了解MIRI的修复机制,也为其治疗提供新的思路。
To investigate the protective effect and mechanism of telomerase reverse transcriptase(TERT)in myocardial ischemia-reperfusion injury(MIRI).The literatures regarding to the role and mechanism of TERT in all kinds of MIRI were reviewed and analyzed comprehensively.The studies show that TERT plays an important role in MIRI.Its main protective effects include the regulation of cellular proliferation and apoptosis,revascularization and mitochondrial function.This paper reviews the protective effect of TERT in MIRI.Further its action mechanism is investigated,which is conducive to understand the repair mechanism of myocardial ischemia-reperfusion injury and also provides a new idea for its treatment.
作者
方智
李姣(综述)
郭应强(审校)
FANG Zhi;LI Jiao;GUO Yingqiang(Department of Cardiovascular Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Department of Pediatrics,West China Second Hospital,Sichuan University,Chengdu,Sichuan 610041,China)
出处
《重庆医学》
CAS
2021年第10期1785-1788,1793,共5页
Chongqing medicine
基金
四川省卫生和健康委员会重点项目(17ZD028)。
关键词
端粒酶逆转录酶
心肌缺血再灌注损伤
保护机制
研究进展
telomerase reverse transcriptase
myocardial ischemia-reperfusion injury
protecting mechanism
research progress
