硒制剂应用于多囊卵巢综合征疗效的Meta分析

Effect of Selenium Preparations on Polycystic Ovary Syndrome: A Meta-Analysis

目的:系统评价硒制剂在治疗多囊卵巢综合征中的疗效。方法:用计算机检索Pubmed、Medline、Embase、Cochrane图书馆、中国生物医学文数据库(CBM),收集硒制剂治疗多囊卵巢综合征的相关随机对照实验,严格按照纳入和排除标准筛选文献,采用Cochrane系统评价员手册5.3对纳入文献进行质量评价,采用Stata 15.0软件进行Meta分析。结果:总共纳入9项RCT,共计509名患者。Meta分析结果提示:干预组体重在硒制剂干预后和对照组无差异,两组胰岛素抵抗相关指标如空腹血糖、血清胰岛素水平和胰岛素抵抗指数也无明显差异,两组血清甘油三酯和低密度脂蛋白水平也无明显差异,两组血清睾酮水平、卵泡刺激素水平和黄体生成素水平也无统计学差异,但硒制剂干预组总胆固醇水平低于对照组。结论:硒制剂在降低多囊卵巢综合征患者体重、改善胰岛素抵抗、调节血脂水平和缓解高雄激素血症方面无明显作用。

Objective To investigate the effect of selenium preparations on polycystic ovarian syndrome.Method The databases including Pubmed,Medline,Embase,Cochrane Library,CBM were searched.Randomized controlled studies of selenium supplements on polycystic ovarian syndrome patients were collected.The literature was selected accordance with inclusion and exclusion criteria.The quality of the research was evaluated by Cochrane System Evaluator Manual 5.3,and the meta-analysis was carried out by Stata 15.0 statistical software.Result A total of 9 RCTs(509 patients)were included.Meta-analysis showed that there were no significant differences in the weight,fasting plasma glucose,insulin level,HOMA-IR,triglycerides,low density lipoprotein,testosterone,follicle stimulating hormone;luteinizing hormone between two groups.The total cholesterol level of the selenium preparation intervention group was lower than that of the control group.Conclusion Supplementation of selenium preparation has no obvious effect on reducing weight,improving insulin resistance,regulating blood lipid level and relieving hyperandrogen in polycystic ovarian syndrome patients.