高迁移率族盒转录因子1与乳腺癌相关性的生物信息学分析

Prediction of relationship between high-mobility group-box transcription factor 1 and breast cancer by bioinformatics analysis

目的分析高迁移率族(high-mobility group,HMG)盒转录因子1(HMG-box transcription factor 1,HBP1)与乳腺癌的相关性。方法通过生物信息学方法分析HBP1基因在乳腺癌中的突变情况、HBP1基因表达量及其与乳腺癌预后的相关性、HBP1基因共表达基因及其与HBP1基因表达的相关性。结果乳腺癌中HBP1基因整体突变率为0.00%,HBP1表达水平明显低于正常组织(P<0.01),且表达水平与乳腺癌预后呈正相关(P<0.001),与HBP1共同发挥生物学功能的相关基因有BTG1、CREBBP和SH3BGRL,在乳腺癌中,HBP1与BTG1、CREBBP表达呈正相关(P<0.01),与SH3BGRL3表达呈负相关(P<0.01)。结论HBP1基因的表达影响乳腺癌的发生发展,并与乳腺癌预后呈正相关。

Objective To analyze the relationship between high-mobility(HMG)-box transcription factor 1(HBP1) and breast cancer. Methods The mutation status of HBP1 gene in breast cancer,expression level of HBP1 gene in breast cancer and its relationship to survival period,and the co-expressed gene of HBP gene as well as its relationship to HBP1 gene in breast cancer were analyzed by bioinformatics analysis. Results The overall mutation rate of HBP1 in breast cancer was 0. 00%. The expression level of HBP1 protein in breast cancer was significantly lower than that in normal tissues(P< 0. 01),which was positively related to the prognosis of breast cancer(P< 0. 001). BTG1,CREBBP and SH3 BGRL were related molecules to the biological function of HBP1. In breast cancer,the expression level of HBP1 was positively related to thoses of BTG1 and CREBBP(P< 0. 01),while was negatively related to that of SH3 BGRL3(P< 0. 01).Conclusion The expression of HBP1 gene influenced the occurrence and development of breast cancer and was positively related to the prognosis of the disease.