预防性mRNA疫苗的研究进展

Progress in research on prophylactic mRNA vaccines

mRNA疫苗作为一种新型的核酸疫苗,其良好的安全性、有效性和快速产业化、低成本等特点使其成为近些年疫苗研究的热点,尤其是应对新发突发传染病疫情防控,显示出独特的优势。目前已建立了多个mRNA疫苗研发平台,在克服mRNA稳定性和递送效率等问题上也取得了阶段性进展,用于感染性疾病的预防、控制和癌症治疗等医学技术领域。本文从mRNA疫苗的构建策略、疫苗递送系统和预防传染病mRNA疫苗的临床及临床前研究现状等方面作一综述,旨在阐明mRNA疫苗用于传染病防控方面的广阔前景。

As a novel nucleic acid vaccine,mRNA vaccine has become a promising vaccine approach because of its safety, effectiveness, rapid production and low-cost, especially its unique advantage in prevention and control of emerging and sudden infectious diseases. With overcoming the issue of the instability and inefficient delivery,several mRNA vaccine platforms have been built and used for the prevention and control of infectious diseases as well as therapy of cancers. In this review we summarized the mRNA design,RNA delivery and research status of clinical or pre-clinical trials to expound the prospects in the field of preventing and controlling the infectious disease in the future.