高敏心肌肌钙蛋白在急性冠脉综合征患者中的临床应用进展

Clinical Application of High-Sensitivity Cardiac Troponin in Patients with Acute Coronary Syndrome

目前的国际指南表明,高敏心肌肌钙蛋白(hs-cTn)已成为心脏组织坏死的主要生物标志物,对于急性冠脉综合征(ACS)的早期诊断至关重要。第五代hs-cTn检测已被广泛应用,在ACS的早期诊断、危险分层和预后评估方面都发挥了重要作用。但在临床实践中,hs-cTn的应用仍存在争议。现回顾近年hs-cTn在疑诊ACS患者中的应用证据及指南,以总结hs-cTn在ACS患者中的临床应用进展。

Current international guidelines demonstrate that high-sensitivity cardiac troponin(hs-cTn)have become a primary biomarker for cardiac tissue necrosis and is essential for early diagnosis of acute coronary syndrome(ACS).The 5th-generation hs-cTn assays have been widely used,which plays an important role in the early diagnosis,risk stratification and prognosis assessment of ACS.However,the application of hs-cTn is still controversial in clinical practice.This article reviews the recent evidence and guidelines of using hs-cTn in patients with suspected ACS to summarize the progress in clinical application of hs-cTn in patients with ACS.