唐山地区孕妇尿碘水平及肌酐校正尿碘指标的效果研究

Study on urinary iodine level and the effect of creatinine correction of urinary iodine index of pregnant women in Tangshan area

目的调查唐山地区不同地域及不同孕期孕妇的尿碘水平,并结合肌酐校正后的尿碘指标进行统计学分析,从而指导本地区孕妇的碘摄入。方法对迁安市、唐海县、唐山市三地361名孕妇的尿液标本进行尿碘和尿肌酐检测。将得到的尿碘数据及肌酐校正后的尿碘数据按地域和孕期各分为三组,对各组数据进行统计学分析。结果不同地域及不同孕期间孕妇尿碘水平的多组比较均显示没有显著性差异(P>0.05),经肌酐校正后的尿碘指标的多组比较也均显示没有显著性差异(P>0.05)。所有孕妇的尿碘中位数为171.3μg/L,各分组的尿碘中位数在160.5~179.3μg/L之间。所有标本中,尿碘值<100μg/L及>500μg/L的标本数占总数的比例为21.6%,在尿碘值经肌酐校正后,此比例为10.5%。结论各分组间的碘营养状况较均衡没有明显差别。所有标本的总体尿碘中位数及各分组的尿碘中位数均在碘足量范围,但都在足量范围下限附近,建议本地孕妇应继续关注自身的碘营养状况。经肌酐校正后的尿碘结果减少了尿量对尿碘结果的影响,更准确地反映了尿碘排泄的实际状况,能够提供更加真实可靠的统计学分析结果。

Objective To investigate the urinary iodine level of pregnant women in different regions and different gestational periods in Tangshan area,and combined with creatinine corrected urinary iodine index for statistical analysis,so as to guide the iodine intake of pregnant women in this region.Methods The urine samples of 361 pregnant women in Qian’an City,Tanghai County and Tangshan City were detected for urinary iodine and creatinine.The urinary iodine data and creatinine corrected urinary iodine data were divided into three groups according to region and pregnancy period,the data of each group were statistically analyzed.Results There was no significant difference in urinary iodine levels among different regions and different gestational periods(P>0.05),there was no significant difference in urinary iodine after creatinine correction(P>0.05).The median urinary iodine of all pregnant women was 171.3μg/L,the median urinary iodine of each group ranged from 160.5μg/L to 179.3μg/L.The proportion of urinary iodine value less than 100μg/L and more than 500μg/L was 21.6%,after creatinine correction,the ratio was 10.5%.Conclusion There was no significant difference in iodine nutritional status among different groups.The total median of urinary iodine of all samples and the median of urinary iodine of each group were in the range of adequate iodine,but they are all near the lower limit of the full range,it is suggested that local pregnant women should continue to pay attention to their iodine nutritional status.The results of urine iodine corrected by creatinine reduced the influence of urine volume on the results of urine iodine,it can reflect the actual situation of urinary iodine excretion more accurately,it can provide more authentic and reliable statistical analysis results.