卡前列素氨丁三醇联合缩宫素预防产后出血的效果观察

Observation on the effect of carboprost tromethamine combined with oxytocin on prevention of postpartum hemorrhage

目的探讨卡前列素氨丁三醇联合缩宫素预防产后出血的效果。方法65例高危产妇,按床尾号单双数分为对照组(32例)和观察组(33例)。两组产妇均实施横切口剖宫产手术,分娩后,对照组产妇使用缩宫素治疗,观察组产妇在对照组基础上使用卡前列素氨丁三醇治疗。比较两组产妇的治疗效果,产后2、10及24 h的出血量,不良反应发生率。结果治疗后,观察组显效22例、有效10例、无效1例;对照组显效17例、有效7例、无效8例。观察组产妇治疗总有效率为96.97%(32/33),高于对照组的75.00%(24/32),差异有统计学意义(P<0.05)。观察组产妇产后2、10、24 h出血量分别为(195.21±42.18)、(258.47±40.16)、(317.81±48.16)ml,均明显少于对照组的(225.46±41.39)、(294.67±41.39)、(374.58±47.65)ml,差异具有统计学意义(P<0.05)。观察组产妇发生呕吐1例、恶心1例;对照组产妇发生呕吐4例、恶心4例、心率加速3例。观察组产妇不良反应发生率为6.06%(2/33),低于对照组的34.38%(11/32),差异具有统计学意义(P<0.05)。结论对高危产妇实施卡前列素氨丁三醇联合缩宫素预防治疗可有效减少产后出血量,提高治疗效果,且不良反应发生率低,具有很高的临床推广价值。

Objective To discuss the effect of carboprost tromethamine and oxytocin on prevention of postpartum hemorrhage.Methods A total of 65 high-risk parturient were divided into control group(32 cases)and observation group(33 cases)according to odd-even bed number.Both groups underwent cross-incision for cesarean section.After delivery,the women in the control group were treated with oxytocin,and the women in the observation group were treated with carboprost tromethamine on the basis of the control group.The therapeutic effect,blood loss at 2,10 and 24 h postpartum and occurrence of adverse reactions were compared between the two groups.Results After treatment,the observation group had 22 excellent cases,10 effective cases and 1 ineffective case;the control group had 17 excellent cases,7 effective cases and 8 ineffective cases.The total effective rate of the observation group was 96.97%(32/33),which was higher than 75.00%(24/32)of the control group,and the difference was statistically significant(P<0.05).The blood loss at 2,10 and 24 h postpartum of the observation group were(195.21±42.18),(258.47±40.16)and(317.81±48.16)ml,which were obviously less than(225.46±41.39),(294.67±41.39)and(374.58±47.65)ml of the control group,and the difference was statistically significant(P<0.05).In the observation group,vomiting occurred in 1 case and nausea occurred in 1 case;in the control group,vomiting occurred in 4 cases,nausea occurred in 4 cases,andheart rate acceleration occurred in 3 cases.The incidence of adverse reactions of the observation group was 6.06%(2/33),which was lower than 34.38%(11/32)of the control group,and the difference was statistically significant(P<0.05).Conclusion The combined treatment of carprost tromethamine and oxytocin for high-risk parturient can effectively reduce the amount of postpartum hemorrhage,improve therapeutic effect,and reduce the incidence of adverse reactions.It has a high clinical promotion value.