奥美拉唑与兰索拉唑分别联合抗生素治疗酒精型消化溃疡的临床疗效

Clinical efficacy of omeprazole and lansoprazole combined with antibiotics respectively in the treatment of alcoholic peptic ulcer

目的探讨奥美拉唑与兰索拉唑分别联合抗生素治疗酒精型消化溃疡的效果。方法选取我院2018年8月至2020年1月收诊的酒精型消化溃疡患者194例为研究对象,以电脑随机法分组,奥美拉唑组患者应用奥美拉唑联合抗生素治疗,兰索拉唑组患者应用兰索拉唑联合抗生素治疗,对比两组的治疗总有效率、临床症状消失时间、不良反应发生率等。结果奥美拉唑组患者治疗总有效率为86.60%,低于兰索拉唑组的96.91%,差异有统计学意义(P<0.05);奥美拉唑患者的腹痛、嗳气、反酸、腹胀、呕吐症状消失时间均长于兰索拉唑组,差异有统计学意义(P<0.05);奥美拉唑组患者的不良反应发生率为11.33%,高于兰索拉唑组的2.06%,差异有统计学意义(P<0.05)。结论兰索拉唑联合抗生素疗法在酒精型消化溃疡患者治疗中应用疗效更好,有利于促进患者临床症状缓解,且用药安全性高,患者耐受力更好,值得推广。

Objective To study the efficacy of omeprazole and lansoprazole combined with antibiotics respectively in the treatment of alcoholic peptic ulcer.Methods A total of 194 patients with alcohol-based digestive ulcer admitted to gastroenterology of our hospital from August 2018 to January 2020 were selected as the research objects and divided into the omeprazole group and the lansoprazole group according to the computer random method.The omeprazole group was treated with omeprazole combined with antibiotics,while the lansoprazole group was treated with lansoprazole combined with antibiotics.The total effective rate of treatment,the disappearance time of clinical symptoms and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the omeprazole group was 86.60%,which was lower than that of the lansoprazole group(96.91%),the difference was statistically significant(P<0.05).The disappearance time of symptoms of abdominal pain,belching,acid reflux,abdominal distension and vomiting in omeprazole group was higher than that in the lansoprazole group,the difference was statistically significant(P<0.001).The incidence of adverse reactions in the omeprazole group was 11.33%,which was higher than that in the lansoprazole group(2.06%),the difference was statistically significant(P<0.05).Conclusion Lansoprazole combined with antibiotics has a better effect in the treatment of patients with alcoholic peptic ulcer,which is conducive to promoting the remission of clinical symptoms in patients,with high safety and better tolerance.It is worthy of promotion.