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艾司氯胺酮预处理在臂丛神经阻滞老年手术患者的应用 被引量:22

Application of esketamine pretreatment in elderly surgical patients under brachial plexus block
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摘要 目的观察艾司氯胺酮预处理在臂丛神经阻滞老年手术患者的应用效果。方法在罗哌卡因臂丛麻醉下行上肢手术老年患者60例随机分为K组和C组,每组30例。K组手术切皮前10 min缓慢静脉注射艾司氯胺酮0.5 mg/kg。记录麻醉前(T0)、臂丛阻滞完毕后15 min(T1)和30 min(T2)及术毕(T3)的SpO2、MAP和HR,并同时检测血清皮质醇(Cor)、肾上腺素(E)、去甲肾上腺素(NE)及血糖(BG)。记录术后不良反应发生情况。结果C组T1~T3时的MAP、HR、NE、E、Cor和BG水平均高于T0(P<0.05),且高于K组(P<0.05)。K组术后需要追加镇痛药的比例小于C组(P<0.05)。术后两组患者均未出现明显不良反应。结论艾司氯胺酮预处理能减少臂丛神经阻滞下上肢手术老年患者的应激反应。 Objective To observe the efficacy of esketamine pretreatment in elderly surgical patients under brachial plexus block.Methods Sixty elderly patients undergoing upper limb surgery under brachial plexus block with 0.33%ropivacaine were assigned into two groups of K and C with 30 cases each.Esketamine 0.5 mg/kg was infused in 10 minutes before skin incision in group K.At the time points of before anesthesia(T0),15 min(T1)and 30 min after brachial plexus block(T2)and at the end of operation(T3),SpO2,MAP and HR were recorded and serum cortisol(Cor),epinephrine(E),norepinephrine(NE)and blood glucose(BG)were detected at the same times.The postoperative adverse responses were observed as well.Results MAP,HR,NE,E,Cor and BG at T1 to T3 in group C were higher than those at T0(P<0.05),which were higher than those in group K(P<0.05).The percentage of the patients using supplemental analgesics postoperatively was higher in group C than that in group K(P<0.05).There were no obvious adverse responses in the two groups.ConclusionEsclamine pretreatment can reduce stress response in elderly patients undergoing upper limb surgery under brachial plexus block.
作者 顾晓霞 庞萍 彭雪 王晶晶 卢悦 徐明坤 GU Xiaoxia;PANG Ping;PENG Xue(Department of Anesthesiology,Affiliated Hospital,Guangdong Medical University,Zhanjiang 524001,CHINA)
出处 《江苏医药》 CAS 2021年第4期356-358,共3页 Jiangsu Medical Journal
基金 广东医科大学科研基金(2XK17046)。
关键词 艾司氯胺酮 预处理 臂丛神经阻滞 Esketamine Pretreatment Brachial plexus block
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  • 1张建蓉,贾小林,孙嘉麟.咪唑安定作为硬膜外阻滞前用药时间的探讨[J].临床麻醉学杂志,2004,20(8):488-489. 被引量:43
  • 2代跃洪.克氏针钢丝内固定治疗锁骨骨折122例[J].实用医学杂志,2005,21(8):783-783. 被引量:4
  • 3陈德胜,金群华,黄建国,李亚平,吕金捍.纯钛重建钢板在成人锁骨骨折中的应用体会[J].实用医学杂志,2005,21(8):829-830. 被引量:5
  • 4MANTZ J. Alpharadrenoceptor agonists: analgesia, sedation, anxiolysis, haemodynamics, respiratory function and weaning [J]. Bailliere's Clin Anaesthesiol, 2000, 14(2): 443-448.
  • 5ANTTILA M, PENTTILA J, HELMINEN A, et al. Bioavailability of dexmedetomidine after extravascular doses in healthy subjects [J]. Br J Clin Pharmacol, 2003, 56(6) : 691-693.
  • 6KAROL MD, MAZE M. Pharmacokinetics and interaction pharmacodynamics of dexmedetomldine in humans [J]. Bailliere's Clin Anaesthesiol, 2000, 14(2): 261-269.
  • 7KAMIBAYASHI T, MAZE M. Clinical uses of α2-adrenergic agonists[J]. Anesthesiology, 2000, 93(5) : 1345-1349.
  • 8LAKHLANI PP, MacMILLAN LB, GUO TZ, et al. Substitution of a mutant alpha2a-adrenerglc receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo[J]. Proc Natl Acad Sci USA, 1997, 94(18): 9950-9955.
  • 9MAKARITSIS KP, JOHNS C, GAVRAS I, et al. Role of alpha (2)-adrenergic receptor subtypes in the acute hypertensive response to hypertonic saline infusion in anephric mice [J]. Hypertension, 2000, 35(2): 609-613.
  • 10SALLINEN J, HAAPALINNA A, VIITAMAA T, et al. Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mlce[J]. J Neurosci, 1998, 18(8) : 3035-3042.

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