青钱柳调节糖脂代谢活性成分及作用机制的研究进展

Research Progress of the Active Components and Mechanism of Cyclocarya paliurus in Regulating Glucolipid Metabolism

青钱柳(Cyclocarya paliurus)是胡桃科青钱柳属植物,近年来因其对改善糖脂代谢紊乱的良好作用日益成为研究热点。目前已从青钱柳中分离得到多种化合物,主要的生物活性成分包括多糖、三萜、黄酮、酚酸等。主要通过保护胰岛细胞、调节胰岛素信号通路、促进葡萄糖利用等发挥改善糖代谢的作用,并通过调控脂质代谢通路、抑制脂质过氧化等发挥改善脂代谢的作用。本文对青钱柳调节糖脂代谢活性成分及作用机制进行综述,为青钱柳防治糖尿病、高血脂、肥胖等代谢疾病提供参考。

Cyclocarya paliurus,the sole plant in its genus belong to the Juglans family,has attracted much attention due to its well-known modulation effect on glucose and lipid metabolism.Up to now,a variety range of bioactive natural compounds such as polysaccharides,triterpenes,flavonoids,and phenolic acids have been isolated from Cyclocarya paliurus.It has been reported that Cyclocarya paliurus exerts its therapeutic effect on glucose metabolism via multiple pathways,including protecting the pancreatic islet cells,regulating the insulin signaling pathway,and enhancing the uptake of utilization of glucose.On the other hand,the lipid metabolism modulation effect of this medicinal plant has been linked to the regulation of related signal cascade as well as inhibition of lipid peroxidation.In this review,we summarized the recent progress on mechanism studies regarding abovementioned activities of Cyclocarya paliurus,highlighting the potential application of this plant in the treatment of diabetes,hyperlipidemia,obesity and other metabolic diseases.