基于图像认知的心理测评技术与17项汉密尔顿抑郁量表的相关性研究

Correlation between mental assessment technology based on image cognition and 17-item Hamilton Depression Scale

目的探索图像认知的心理测评技术评分与17项汉密尔顿抑郁(HAMD-17)量表在评估抑郁症严重程度中的相关性。方法回顾性连续纳入北京安定医院门诊就诊的抑郁症患者113例。使用HAMD-17对抑郁症患者进行抑郁严重程度评估,同时指导患者完成基于图像认知的心理测评。使用偏相关分析和多因素线性回归分析方法评价图像认知评分与HAMD-17量表评估的疾病严重程度之间的相关性以及影响因素,并采用受试者工作特征曲线分析图像认知评分对抑郁症患者严重程度的预测价值。结果HAMD-17量表总评分平均(19.31±5.30)分,其中轻度抑郁18例,HAMD-17总分为7~13分,平均(11.44±1.46)分;中度抑郁40例,HAMD-17总分为14~19分,平均(16.75±1.69)分;重度及以上抑郁55例,HAMD-17总分为≥20分,平均(23.78±3.03)分;不同程度抑郁患者间HAMD-17评分差异有统计学意义(F=210.99,P<0.001)。图像认知评分平均(51.02±23.22)分,其中48.7%(55/113)为重度及以上抑郁症患者,其图像认知评分平均为(44.87±21.81)分;轻度、中度抑郁患者图像认知评分平均为(57.06±22.91)、(59.35±22.82)分;不同抑郁程度患者间图像认知评分差异有统计学意义(F=5.42,P<0.01),重度及以上抑郁图像认知评分明显低于轻度、中度(均P<0.05)。偏相关分析结果显示,图像认知评分与HAMD-17量表总分呈负相关(r=-0.31,P<0.05)。线性回归分析结果显示,图像认知评分与HAMD17量表总分呈线性相关(t=-3.03,P=0.003)。受试者工作特征曲线分析结果显示,图像认知评分能够有效区分出重度抑郁症患者(曲线下面积为0.677,P=0.001),当截断值为52分时,其敏感度为67.2%,特异度为69.1%。结论图像认知评分与HAMD-17量表总分在抑郁症严重程度上具有相关性,所反映抑郁症状严重程度趋势一致,具有一定的评估抑郁症状严重程度的价值。

Objective To explore the correlation between the scores of mental assessment techniques of image cognition and 17 items of Hamilton Depression Scale(HAMD-17)in assessing the severity of depression.Methods A total of 113 patients with depression were retrospectively consecutively enrolled from the outpatient department of Beijing Anding Hospital.HAMD-17 was used to assess the severity of depression,and the patients were instructed to complete mental assessment based on image cognition.Partial correlation analysis and multivariate linear regression analysis were used to evaluate the correlation between image cognition score and disease severity assessed by HAMD-17 scale.The predictive value of image cognitive score on the severity of depression was analyzed by the receiver operating characteristic(ROC)curve.Results The average score of HAMD-17 was(19.31±5.30),including 18 cases of mild depression,HAMD-17 ranged from 7 to 13,with an average score of(11.44±1.46);40 cases of moderate depression,HAMD-17 ranged from 14 to 19,with an average score of(16.75±1.69);55 cases of severe disease and above,HAMD-17 over 20(including 20),with an average score of(23.78±3.03).There were significant differences in HAMD-17 scores among patients with different degrees of depression(F=210.99,P<0.001).The average score of image cognition was(51.02±23.22),of which 48.7%(55/113)were patients with severe depression and above,and the average score of image cognition was(44.87±21.81);the average score of image cognition was(57.06±22.91)and(59.35±22.82)in patients with mild and moderate depression.There was significant difference in image cognitive score among patients with different degrees of depression(F=5.42,P<0.01).The image cognitive score of severe and above depression was significantly lower than that of mild and moderate depression(all P<0.05).Partial correlation analysis showed that the image cognitive score was negatively correlated with the total score of HAMD-17(r=-0.31,P<0.05).Linear regression analysis showed that there was a linear correlation between the image cognitive score and the total score of HAMD-17(t=-3.03,P=0.003).The results of ROC curve analysis showed that the image cognitive score could effectively distinguish patients with major depression(area under the curve was 0.677,P=0.001).When the cut-off value was 52,the sensitivity was 67.2%,and the specificity was 69.1%.Conclusions The image cognitive score and HAMD-17 scale have correlation with the severity of depression,which reflects the trend of depression severity,and has a certain value in evaluating the severity of depression.