东风菜2种提取物的抗炎作用

The Anti-inflammatory Effect of Two Extracts from Scabrous Doellingeria Rhizome and Root

目的对东风菜水和醇2种提取物的抗炎效果进行评价。方法采用水和75%乙醇2种溶剂分别对东风菜药材进行提取,通过二甲苯致小鼠耳肿胀实验、冰醋酸致小鼠腹腔通透性实验,观察东风菜2种提取物的抗炎效果。结果与生理盐水组比较,东风菜2种提取物高(7.2 g/kg)、低(3.6 g/kg)剂量组对二甲苯致小鼠耳肿胀有很明显的抑制作用,差异有统计学意义(P<0.05),且存在量效关系;高剂量组(7.2 g/kg)对冰醋酸致小鼠腹腔通透性具有抑制作用(P<0.05)。结论东风菜具有较好的抗炎作用,水提物的抗炎效果优于醇提物。

Objective To evaluate anti-inflammatory effect of water and alcohol extracts from Scabrous Doellingeria Rhizome and Root.Methods Water and 75%ethanol were used to extract the medicinal materials of Scabrous Doellingeria Rhizome and Root.The anti-inflammatory effects of two extracts of Scabrous Doellingeria Rhizome and Root on mice ear swelling induced by xylene and abdominal permeability induced by acetic acid were observed.Results Compared with the normal saline group,the high(7.2g/kg)and low(3.6g/kg)extracts of the two kinds of Scabrous Doellingeria Rhizome and Root had a significant inhibitory effect on the ear swelling induced by xylene in mice,and the difference was statistically significant(P<0.01,P<0.05),and there was a dose-effect relationship.The high dose group(7.2g/kg)had a significant inhibitory effect on abdominal permeability induced by glacial acetic acid in mice(P<0.05).Conclusion The Scabrous Doellingeria Rhizome and Root has a good anti-inflammatory effect,anti-inflammatory effect of water extract was better than that of alcohol extract.