右美托咪定在重度子痫前期剖宫产术后患者中应用及维持血流动力学水平稳定的思考

Application of dexmedetomidine in patients with severe preeclampsia after cesarean section and consideration of maintaining stable hemodynamic level

目的分析右美托咪定在重度子痫前期剖宫产术后患者中应用及维持血流动力学水平稳定的效果。方法选取100例重度子痫前期剖宫产术患者,依据入院时间顺序分为对照组与试验组,每组50例。对照组术后采取咪达唑仑,试验组术后采取右美托咪定,对比两组术后6 h、12 h和24 h血流动力学水平及不良反应发生情况。结果术后6 h,两组患者收缩压(SBP)、舒张压(DBP)水平比较,差异无统计学意义(P>0.05),试验组患者6 h心率(HR)水平慢于对照组,差异具有统计学意义(P<0.05);术后12 h、24 h,试验组SBP、DBP、HR水平均显著低于对照组,差异具有统计学意义(P<0.05)。试验组不良反应发生率为8.0%,明显低于对照组的28.0%,差异具有统计学意义(P<0.05)。结论重度子痫前期剖宫产术后应用右美托咪定可以逐步稳定患者血流动力学水平,减少不良反应的发生,具有临床应用价值。

Objective To analyze the eff ect of dexmedetomidine in patients with severe preeclampsia after cesarean section and to maintain the stable hemodynamic level.Methods A total of 100 patients with severe preeclampsia underwent cesarean section were divided into control group and experimental group according to admission time sequence,with 50 cases in each group.The control group was treated with midazolam after surgery,and the experimental group was treated with dexmedetomidine after surgery.The hemodynamic indexes and the incidence of adverse reactions were compared between the two groups at 6,12 and 24 h after surgery.Results At 6 h after operation,there were no signifi cant diff erences in systolic blood pressure(SBP)and diastolic blood pressure(DBP)between 2 groups(P>0.05),The 6h heart rate(HR)level in experimental group was slower than that in control group,and the diff erence was statistically signifi cant(P<0.05).12 h and 24 h after surgery,the levels of SBP,DBP and HR in experimental group were signifi cantly lower than those in control group,with statistical signifi cance(P<0.05).The eincidence of ADR in experimental group was 8.0%,which was signifi cantly lower than that in control group(28.0%),and the diff erence was statistically signifi cant(P<0.05).Conclusion The application of dexmedetomidine after cesarean section for severe preeclampsia can gradually stabilize the hemodynamic indexes and reduce the occurrence of adverse reactions,which has clinical application value.