中西医结合干预卒中后认知障碍效果的Meta分析

A Meta-analysis of the Effect of Integrated Traditional Chinese and Western Medicine Intervention on Cognitive Impairment After Stroke

目的:通过Meta分析系统评价中西医结合干预卒中后认知障碍的效果。方法:检索中国学术期刊全文数据库(CNKI)、万方数据库(WANFANG)、维普(VIP)以及中国生物医学文献数据库(CBMdisc),年限为2017年1月至2020年5月,全面收集相关原始研究。采用cochrane系统评价方法对文献进行质量评价。提取资料后用RevMan 5.3软件进行Meta分析。结果:共纳入4篇RCT,409例患者,采用固定效应模型进行合并总效应量。蒙特利尔认知评估量表(MoCA)评分差值的Meta分析结果显示均值差(MD)=3.92,95%CI(3.11—4.74),提示中西医结合疗法治疗卒中后认知障碍(PSCI)效果优于单纯西医疗法(Z=9.42,P<0.05),漏斗图基本对称,提示文献发表偏倚较小。结论:在临床治疗中,中西医结合疗法优于单纯西医治疗,应大力推广祖国医学,发挥中西医结合优势。

Objective To the Meta analysis system to evaluate the effect of Chinese and western medicine combined intervention in post-stroke cognitive impairment.Methods Retrieve Chinese Academic Journal Full-text Database(CNKI),Wanfang Database(WANFANG),VIP information and Chinese Biomedical?Database(CBMdisc),for a period of January 2017 to May 2020,and comprehensively collect relevant original research.The cochrane system evaluation method was used to evaluate the quality of the literature,and after the data was extracted,Meta analysis was performed using RevMan 5.3 software.Results A total of 4 RCTs and 409 patients were included,and the total effect size was combined using a fixed effect model.The results of a meta-analysis of the difference in scores of the Montreal Cognitive Assessment Scale(MoCA)showed that the mean difference(MD)=3.92,95%CI(3.11-4.74),suggesting that the combination of traditional Chinese and western medicine treatment of post-stroke cognitive impairment(PSCI)is effective In the simple western medicine method(Z=9.42,P<0.05),the funnel chart is basically symmetrical,suggesting that the publication bias is relatively small.Conclusion In clinical treatment,integrated traditional Chinese and western medicine therapy is superior to simple western medicine treatment.Motherland medicine should be vigorously promoted to take advantage of integrated traditional Chinese and western medicine.