宁泌泰胶囊联合抗生素治疗慢性前列腺炎的效果及不良反应的meta分析

Efficacy and adverse effects of Ningmitai Capsules combined with antibiotics in the treatment of chronic prostatitis:A meta-analysis

目的:评价宁泌泰治疗慢性前列腺炎(CP)的疗效、疗程及不良反应。方法:检索中国知网(CNKI)、万方数据库、中国优秀硕士/博士学位论文数据库、维普中文科技期刊数据库(VIP)、Cochrane图书馆、Pubmed、EMBASE、中国学术会议论文数据库中截至到2019年10月的宁泌泰治疗CP文献,用Jadad量表评价文献质量,用Stata14软件进行meta分析。结果:纳入文献20篇,共计3558例(观察组1807例,对照组1751例)。宁泌泰联合喹诺酮类、四环素类、大环内酯类抗生素治疗CP的有效率与单用同类抗生素相比,其优势比(RR)分别为1.270(1.215,1.328)、1.232(1.132,1.340)、1.239(1.130,1.359)。随着疗程的增加(2、4、8周),宁泌泰联合抗生素治疗CP的有效率RR(95%CI)分别为RR_(2)=1.256(1.185,1.330)、RR_(4)=1.245(1.165,1.330)、RR_(8)=1.244(1.131,1.369),疗程为4周及8周有效率的优势比略低于2周疗程。宁泌泰联合抗生素用药与单独抗生素用药组相比,不良反应出现率差异无统计学意义(P=0.441)。结论:宁泌泰联合抗生素治疗CP的疗效优于单独使用抗生素,尤其合并喹诺酮类抗生素的疗效相较于其他类别抗生素更好;合并用药与单独用药的不良反应发生率没有差异;用药疗程长短并不能决定治疗的效果,故宁泌泰胶囊联合抗生素治疗CP值得在临床上进一步推广使用。

Objective:To study the effect,treatment course and adverse reactions of Ningmitai Capsules(NMT)in the treatment of chronic prostatitis(CP).Methods:We searched the CNKI,Wanfang,COMDD and VIP databases,Cochrane Library,PubMed,EMBASE and Chinese academic conference papers for related articles before October 2019 on the treatment of CP with NMT,evaluated the quality of the literature with the Jadad Scale,and conducted a meta-analysis using the Stata14 software.Results:Totally,20 articles were included in this study,involving 3558 cases of CP,1807 in the observation group and 1751 as controls.In the treatment of CP,NMT combined with quinolone,tetracycline or macrolide exhibited remarkably better effect than any of the above antibiotics used alone(RR[95%CI]:1.270[1.215-1.328],1.232[1.132-1.340]and 1.239[1.130-1.359],respectively)and the combination therapy also showed a higher total efficacy after 2,4 and 8 weeks of medication(RR[95%CI]:1.256[1.185-1.330],1.245[1.165-1.330]and 1.244[1.131-1.369],respectively),though a little lower at 4 and 8 than at 2 weeks.There was no statistically significant difference in the incidence rate of adverse reactions between the NMT combination and antibiotics alone groups(P=0.441).Conclusion:NMT combined with antibiotics,particularly with quinolone,is superior to antibiotics alone in the treatment of CP,though with no statistically significant difference in the incidence rate of adverse reactions between the two options.The length of medication does not inference the therapeutic effect.