甘草荆防汤治疗慢性荨麻疹的临床疗效回顾性分析

Retrospective Analysis of Clinical Efficacy of Gancao Jing Fang Decoction in Treating Chronic Urticaria

【目的】分析甘草荆防汤治疗慢性荨麻疹的临床疗效。【方法】采用回顾性研究方法,选取2019年8月~2020年5月在深圳市中医院皮肤科就诊的100例慢性荨麻疹患者,根据是否运用甘草荆防汤治疗分为观察组和对照组,每组各50例。治疗组给予甘草荆防汤加减治疗,对照组给予常规中医辨证论治处方治疗(风热犯表型运用消风散加减,风寒束表型运用桂枝麻黄各半汤加减,血虚风燥型运用当归饮子加减),疗程为2个月。观察2组患者治疗前后荨麻疹活动性评分(UAS)的变化情况,并评价2组患者的临床疗效。【结果】(1)治疗2个月后,观察组的总有效率为94.0%(47/50),对照组为88.0%(44/50),组间比较,观察组的疗效明显优于对照组,差异有统计学意义(P<0.01)。(2)治疗后,2组患者的UAS评分均较治疗前明显下降(P<0.01),且观察组对USA评分的下降作用明显优于对照组,差异有统计学意义(P<0.01)。【结论】甘草荆防汤治疗慢性荨麻疹疗效显著,其疗效优于常规中医辨证论治处方治疗。

Objective To investigate the clinical efficacy of Gancao Jing Fang Decoction in the treatment of chronic urticaria.Methods The data of 100 patients with chronic urticaria who were treated in the Department of Dermatology of Shenzhen Traditional Chinese Medicine Hospital from August 2019 to May 2020 were retrospectively analyzed.The patients were divided into observation group and control group according to the medication of Gancao Jing Fang Decoction or not,and 50 cases in each group.The observation group was treated with oral use of modified Gancao Jing Fang Decoction,and the control group was treated with the conventional prescriptions for various syndrome types,i.e.,the modified Xiaofeng Powder for the syndrome of wind-heat attacking the exterior,modified Mahuang Guizhi in Half Decoction for the syndrome of wind-heat attacking the exterior,and modified Danggui Yinzi for the syndrome of wind dryness due to blood deficiency.The course of the treatment for the two groups lasted 2 months.Before and after treatment,the urticaria activity scores(UAS)in the two groups were compared,and the clinical efficacy in the two groups after treatment was evaluated.Results(1)After 2 months of treatment,the total effective rate in the observation group was 94.0%(47/50)and that in the control group was 88.0%(44/50).The intergroup comparison showed that the clinical efficacy in the observation group was superior to that in the control group,and the difference was statistically significant(P<0.01).(2)After treatment,the UAS of the two groups were decreased significantly(P<0.01 in comparison with those before treatment),and the decrease of the scores in the treatment group was superior to that in the control group,the difference being statistically significant(P<0.01).Conclusion Gancao Jing Fang Decoction in the treatment of chronic urticaria is effective in treating chronic urticaria,and its effect is superior to that of the conventional prescriptions.