保定市非吸烟人群肺癌危险因素病例对照研究

Case-control study on risk factors for lung cancer among nonsmokers in Baoding

目的探讨保定市非吸烟人群肺癌的危险因素,为制定癌症防治措施提供依据。方法应用1∶2配对病例对照方法,收集保定市2015年以来的非吸烟肺癌新发病例250例,按照性别、年龄、不吸烟等配对因素选取对照。收集有关危险因素的暴露情况,采用单因素及多因素Logistic回归分析筛选肺癌的主要危险因素。结果单因素分析发现有8个暴露因素与非吸烟人群肺癌的发生有关。多因素分析后发现:非吸烟人群肺癌的危险因素是被动吸烟指数≥50人·年、经常食用腌制品、恶性肿瘤家族史,而保护因素是睡眠情况好以及经常食用蔬菜。结论肺癌的发生是多种因素的结果,应有针对性地采取预防与控制措施。

Objective To investigate the risk factors of lung cancer among nonsmokers,and to provide evidences for the development of cancer control.Methods A 1∶2 matched case-control method was carried out,250 non-smoking patients with lung cancer since 2015 in Baoding were admitted,the controls were selected according to matching factors including the gender,age and non-smoking.The exposure conditions related to danger risks are collected.Major risk factors for lung cancer were analyzed by univariate and multivariate conditional logistic regression analysis.Results Eight exposure factors were found to be related to the lung cancer of non-smoking groups by using univariate analysis.The multivariate Logistic regression showed that passive smoking index≥50 person·year,consumption of salty and dry food,family history of cancer were risk factors,while good sleep and high consumption of vegetables were protective factors.Conclusion The onset of lung cancer is the result of many factors,and prevention and control measures should be taken.