小剂量喹硫平联合齐拉西酮对精神分裂症稳定期患者的疗效观察

Effect of low-dose quetiapine combined with ziprasidone on stable schizophrenia

目的探究小剂量喹硫平联合齐拉西酮在稳定期精神分裂症患者中的应用效果及其对患者心功能指标、心电图的影响。方法抽取2017年1月至2019年2月于驻马店市第二人民医院收治的86例稳定期精神分裂症患者为受试对象,按照随机数字表法分为对照组和联合组,每组43例。对照组予以齐拉西酮进行治疗,联合组在对照组基础上联合小剂量喹硫平进行治疗。比较两组患者治疗后症状改善效果,比较两组患者治疗前、治疗8周后的心功能指标和心电图参数情况,比较两组患者治疗过程中不良反应发生情况。结果治疗后,两组患者的临床症状均明显改善,且联合组患者总有效率(93.02%,40/43)高于对照组(76.74%,33/43),P<0.05。治疗8周后,两组患者肌酸激酶(CK)、乳酸脱氢酶(LDH)水平均较治疗前下降,且联合组CK、LDH水平低于对照组(P<0.05)。治疗8周后,两组患者校正QT间期(QTc)均较治疗前升高,且联合组高于对照组(P<0.05)。治疗期间两组患者不良反应发生情况比较差异未见统计学意义(P>0.05)。结论小剂量喹硫平联合齐拉西酮治疗稳定期精神分裂症患者临床症状改善效果较好,在短期内对患者心功能指标不存在负面影响,但可导致患者的心电图参数异常。

Objective To investigate the effect of low-dose quetiapine combined with ziprasidone on stable schizophrenia,and its influences on cardiac function indexes and electrocardiogram.Methods A total of 86 patients with stable schizophrenia treated in Zhumadian Second People’s Hospital from January 2017 to February 2019 were selected as subjects.And they were divided into control group and combined group by random number table method,with 43 cases in each group.Patients in control group were treated with ziprasidone.And patients in combined group were treated with low-dose quetiapine,based on the treatment of control group.The differences in improvement effect of symptoms were compared between the two groups after treatment.And the cardiac function indexes and electrocardiogram parameters were compared between the two groups before treatment and after 8 weeks of treatment.The adverse reactions were compared between the two groups during treatment.Results After treatment,the clinical symptoms of the two groups were significantly improved,and the total effective rate in combined group(93.02%,40/43)was higher than that in the control group(76.74%,33/43),P<0.05.After 8 weeks of treatment,the levels of creatine kinase(CK)and lactate dehydrogenase(LDH)in the two groups decreased,compared with those before treatment,and the levels of CK and LDH in combined group were lower than those in control group(P<0.05).After 8 weeks of treatment,the corrected QT interval(QTc)of the two groups was higher than that before treatment,and the QTc in combined group was higher than that in control group(P<0.05).There was no significant difference in the adverse reactions between the two groups during treatment(P>0.05).Conclusions Low-dose quetiapine combined with ziprasidone has a better effect on improving the clinical symptoms of patients with stable schizophrenia,and has no negative effect on cardiac function indexes in short term,but it can result in abnormal electrocardiogram parameters.