呼吸康复训练联合噻托溴铵在老年稳定期中重度慢性阻塞性肺疾病患者中的应用分析

Application of respiratory rehabilitation training combined with tiotropium bromide in elderly patients with moderate to severe stable COPD

目的探讨呼吸康复训练联合噻托溴铵治疗老年稳定期中重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的临床疗效。方法选取2017年11月至2019年9月本院就诊的老年稳定期中重度COPD患者100例为研究对象,采用随机数字表法将患者分为两组,各50例。对照组男39例,女11例,年龄(68.59±2.49)岁;观察组男37例,女13例,年龄(69.93±2.37)岁。对照组给予噻托溴铵吸入治疗,观察组采用呼吸康复训练联合吸入噻托溴铵治疗。比较两组治疗前、3个月后的临床症状评分、呼吸困难量表评分、6 min步行距离(6MWD)测试和肺功能[第1秒用力呼气容积占预计值的百分比(FEV1%)、第1秒用力呼气容积与用力肺活量的比值(FEV1/FVC)]。结果观察组治疗后的临床症状评分、呼吸困难量表评分分别为(3.97±1.13)分、(1.73±0.62)分,均显著低于治疗前(5.62±1.75)分、(2.55±0.58)分,与对照组治疗后(4.58±1.24)分、(2.15±0.47)分比较,差异均有统计学意义(均P<0.05)。两组患者治疗后的6MWD、FEV1%、FEV1/FVC指标均显著高于治疗前,差异均有统计学意义(均P<0.05);治疗后,观察组6MWD、FEV1%、FEV1/FVC指标分别为(533.38±114.09)m、(70.62±0.24)%、(64.08±0.32)%,均显著高于对照组(447.57±135.16)m、(60.18±0.25)%、(60.26±0.25)%,差异均有统计学意义(均P<0.05)。结论呼吸康复训练联合噻托溴铵可缓解老年稳定期中重度COPD患者的临床症状,改善肺功能,增强运动耐力。

Objective To explore the clinical efficacy of respiratory rehabilitation training combined with tiotropium bromide in the treatment of elderly patients with moderate to severe stable chronic obstructive pulmonary disease(COPD).Methods One hundred elderly patients with moderate to severe stable COPD treated in our hospital from November 2017 to September 2019 were divided into a control group and an observation group with the random number table,with 50 cases in each group.There were 39 males and 11 females in the control group,with the age of(68.59±2.49)years old;there were 37 males and 13 females in the observation group,with the age of(69.93±2.37)years old.The control group was given inhalation therapy with tiotropium bromide,and the observation group was given respiratory rehabilitation training combined with inhalation therapy with tiotropium bromide.The clinical symptom score,dyspnea scale score,6-minute walking distance(6MWD)test,and lung function(FEV1%,FEV1/FVC)were compared between the two groups before and after 3 months of treatment.Results The clinical symptom score and dyspnea scale score of the observation group after treatment[(3.97±1.13)points and(1.73±0.62)points]were lower than those before treatment[(5.62±1.75)points and(2.55±0.58)points]and those in the control group after treatment[(4.58±1.24)points and(2.15±0.47)points](all P<0.05).The 6MWD,FEV1%,and FEV1/FVC of the two groups after treatment were higher than those before treatment(all P<0.05);the 6MWD,FEV1%,and FEV1/FVC of the observation group were(533.38±114.09)m,(70.62±0.24)%,and(64.08±0.32)%,which were higher than those of the control group[(447.57±135.16)m,(60.18±0.25)%,and(60.26±0.25)%](all P<0.05).Conclusion Respiratory rehabilitation training combined with tiotropium bromide can relieve the clinical symptoms of elderly patients with moderate to severe stable COPD,improve the lung function,and enhance the exercise endurance.