显微镜下多血管炎肺损害发病机制及治疗进展

Research progress in pathogenesis and treatment of pulmonary injury in microscopic polyangiitis

显微镜下多血管炎(microscopic polyangiitis,MPA)是一种以累及小血管为主的系统性血管炎,可造成全身多个重要组织、脏器的损害。肺是其常见的受累器官,主要可表现为肺间质纤维化、弥漫性肺泡出血(diffuse alveolar hemorrhage,DAH)等。近年来随着对MPA肺损害发病机制认识的不断深入,对MPA肺受累的治疗也取得了新的进展。

Microscopic polyangiitis(MPA)is a kind of systemic vasculitis which mainly involves small blood vessels and can cause damage to multiple important issues and organs throughout the body.The lung is a common affected organ,which mainly manifests as pulmonary interstitial fibrosis,diffuse alveolar hemorrhage and so on.In recent years,with the in-depth understanding of the pathogenesis of pulmonary injury in MPA,new progress has been made in the treatment of lung involvement in MPA.