卵圆孔未闭与隐源性卒中及其危险因素之间关系的研究进展

Research progress in the relationship between patent foramen ovale and cryptogenic stroke and its risk factors

隐源性卒中占所有缺血性卒中的30%~40%,随着影像学技术的发展,其发病率仍居高不下。虽然多种危险因素(既往卒中、高血压、静脉血栓病史、高脂血症、高同型半胱氨酸血症等)被提出,高风险的卵圆孔未闭却是近年来才被认识的隐源性卒中的危险因素。越来越多的研究表明卵圆孔未闭和隐源性卒中密切相关。对于合适的患者而言,卵圆孔未闭封堵术可明显降低隐源性卒中患者的卒中复发风险。

Cryptogenic stroke accounts for about 30%–40%of all ischemic strokes.With the development of imaging technology,its incidence remains high.Although several risk factors(previous stroke,hypertension,history of venous thrombosis,hyperlipidemia,hyperhomocysteinemia,etc.)have been proposed,the high-risk patent foramen ovalis has been recognized as a risk factor for cryptogenic stroke in recent years.More and more studies have shown that the patent foramen ovale is closely related to cryptogenic stroke.With an appropriate patient selection,the patent foramen ovale closure can significantly reduce the risk of stroke recurrence in patients with cryptic stroke.