应用OCT探究眼压与筛板参数的关系

The relationship between intraocular pressure and lamina cribrosa parameters by OCT

筛板的变形与血流减少一直被视作青光眼视神经轴突损伤的首发因素。病理性眼压升高与青光眼的发生发展间有紧密关系。通过OCT技术衡量筛板及周边参数随眼压变化来研究青光眼发病机制受到了广泛关注。研究表明筛板深度(LCD)、筛板前表面厚度(PTT)、筛板曲率指数(LCCI)以及视盘血管密度等参数均与眼压具有相关性。眼压升高可对筛板结构和血流双重作用而影响青光眼的进展。但眼压的作用并非影响筛板的唯一因素。

The deformation of lamina cribrosa and the decrease of blood flow have been regarded as the first factors of optic nerve axon damage in glaucoma.Pathological intraocular pressure increase has been proved to be closely related to the occurrence and development of glaucoma.With the continuous improvement of OCT technology,the study of the pathogenesis of glaucoma by measuring the changes of lamina cribrosa and peripheral parameters with intraocular pressure has also been widely concerned around the world.A large number of studies have shown that the lamina cribrosa depth(LCD),the prelaminar tissue thickness(PTT),the lamina cribrosa curvature index(LCCI)and the optic nerve head vascular density are all correlated with intraocular pressure by OCT and OCT technology.Higher intraocular pressure can affect the progress of glaucoma through its dual effects on lamina cribrosa structure and blood flow.However,the role of intraocular pressure is not the only factor affecting the lamina cribrosa.