自拟中药“舒通脐贴”对便秘犬脂代谢的影响

Clinical Efficacy of Chinese Medicine Shutong Umbilicus Paste on Canine Constipation of Lipid Metabolism

目的:研究自拟中药“舒通脐贴”对便秘犬脂代谢的影响。方法:选择18只的成年中华田园犬,雌雄各半,采用肉类饮食联合药物的造模方法制备便秘模型,按照体重给予试验犬火腿肠和3 mg/kg复方地芬诺酯每日中午口服,14 d制成STC(慢传输型便秘)模型。采用君二臣三佐五使二配方,制成创新复方中药“舒通脐贴”。按体重相近的原则分为对照组、舒通脐贴组和通便灵组,每日分别给予空白脐贴、舒通脐贴和通便灵胶囊,进行14 d试验。在分别对试验前(第0天)、便秘模型(第14天)、给药后(第28天)试验犬采血,分离血液,提取血清。通过眼观排便次数以及生化分析仪测定各组血清胆固醇水平、甘油三酯、高密度脂蛋白、低密度脂蛋白并进行数据分析。结果:自拟中药舒通脐贴能够明显增加排粪次数,降低血清胆固醇、甘油三酯水平,提高高密度脂蛋白水平,对低密度脂蛋白无明显影响。结论:通过犬试验表明,自拟中药配方舒通脐贴可促进便秘犬的排便,加快脂肪的代谢,在一定程度上具有抑制高脂血的作用。

Objective:To investigate the effects of Shutong umbilicus paste on canine constipation of lipid metabolism.Methods:18 cases of constipation were treated by drug combined with diet control,female canines and male canines number each half,according to the weight experimental canines were given ham sausage and 3 mg/kg compound diphenoxylate at noon for 14 days to establish the canine model of STC.Using the traditional Chinese medicine that monarch two,minister three,assistant five and guide two to make the“Shutong umbilicus paste”.According to the principle of similar weight,the canines were divided into the control group,the drug group and the drug Tongbianling group.Blank umbilicus paste,Shutong umbilicus paste and Tongbianling capsules were given every day for 14 d test.Blood was collected before the test(0 d),in the constipation model(14 d),and after the drug administration(28 d)and the blood was seperated and extract the serum was extracted.Through observing the times of defecation and analyzing the biochemical analyzer determination of serum cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol was decided.Results:Self-designed Chinese medicine Shutong umbilicus paste can significantly increase the number of defecation times,reduce the level of total cholesterol,low density lipoprotein and increase the level of high density lipoprotein.Conclusion:The results of dog experiments show that the self-formulated traditional Chinese medicine Shutong umbilical paste can promote the defecation of constipated dogs,accelerate fat metabolism,and have some effect of lowering blood lipids of endogenous.