含溴结构域蛋白2结构与功能的研究进展

Advances in the Structure and Function of Bromodomain-Containing Protein 2

含溴结构域蛋白2(bromodomain-containing protein 2,BRD2)具有两个串联的溴结构域和一个末端外结构域,是溴结构域和末端外结构域蛋白家族成员之一。BRD2蛋白能够特异性结合组蛋白乙酰化赖氨酸,参与基因的转录调控、染色质重塑和细胞增殖与凋亡等生物学活动。近年来研究表明,BRD2蛋白通过溴结构域和乙酰化组蛋白之间的表观遗传相互作用来调控基因转录和细胞周期、神经发育、炎症和脂肪生成,并且在肿瘤细胞增殖以及病毒感染和复制过程中也有着重要作用。该文主要从BRD2蛋白的结构特征、细胞功能和参与病毒复制的作用机制等方面进行综述,以期为深入研究BRD2蛋白的功能提供参考。

BRD2 (bromodomain-containing protein 2) is a member of the bromodomain and extra-terminal domain family,which has two tandem bromodomains and one extra-terminal domain.BRD2 protein can specifically bind histone acetylated lysine and participate in gene transcriptional regulation,chromatin remodeling,cell proliferation and apoptosis and other biological activities.Recently,studies have shown that BRD2 regulates gene transcription,cell cycle,neurodevelopment,inflammation and lipogenesis through the epigenetic interaction between bromodomain and acetylated histone in the process of cell proliferation and differentiation,and also plays important roles in promoting tumor cell proliferation and mediating potential virus infection and replication.This review focuses on the structural characteristics and cellular functions of BRD2 and also the mechanisms of BRD2-participated in virus replication,which provide useful references for further studying the functions of BRD2.